1887

Abstract

Accurate susceptibility results on antibiotic-resistant bacteria are essential for proper treatment of infections. In this study, 100 metallo-β-lactamase (MBL)-producing strains and 95 isolates with carbapenemase (KPC) were tested for carbapenem susceptibility using two automated platforms, the Phoenix and Vitek-2 systems, and a manual Etest. Phoenix showed higher categorical agreements (97 % for imipenem and 94 % for meropenem) compared with those from Vitek-2 (92 and 74 %) and Etest (89 and 96 %), respectively, when testing MBL strains. Categorical agreement for imipenem tests with KPC-producing strains was 88.4 % with the Phoenix system, 83.2 % with the Vitek 2 system and 90.5 % with the Etest. Categorical agreement was 100 % for all tests with ertapenem. In conclusion, the Phoenix system demonstrated a higher accuracy than Vitek-2 in testing carbapenemase-producing strains, particularly in MBL strains.

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/content/journal/jmm/10.1099/jmm.0.000067
2015-06-01
2021-10-24
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