1887

Abstract

Previous work on the subclones within ST131 predominantly involved isolates from Western countries. This study assessed the prevalence and antimicrobial resistance attributed to this clonal group. A total of 340 consecutive, non-duplicated urinary isolates originating from four clinical laboratories in Hong Kong in 2013 were tested. ST131 prevalence among the total isolates was 18.5 % (63/340) and was higher among inpatient isolates (23.0 %) than outpatient isolates (11.8 %, <0.001), and higher among isolates from patients aged ≥65 years than from patients aged 18–50 years and 51–64 years (25.4 vs 3.4 and 4.0 %, respectively, <0.001). Of the 63 ST131 isolates, 43 (68.3 %) isolates belonged to the 30 subclone, whereas the remaining isolates belonged to 41 ( = 17), 54 ( = 2) and 22 ( = 1). All 30 isolates were ciprofloxacin-resistant, of which 18.6 % (8/43) belonged to the 30-Rx subclone. Twenty-six (41.3 %) ST131 isolates were ESBL-producers, of which 19 had (12 non-30-Rx, two 30-Rx and five H41), six had (five non-30-Rx and one 30-Rx) and one was -negative (30). In conclusion, ST131 accounts for a large share of the antimicrobial-resistant isolates from geriatric patients. Unlike previous reports, ESBL-producing ST131 strains mainly belonged to non-30-Rx rather than the 30-Rx subclone, with as the dominant enzyme type.

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2015-03-01
2020-10-23
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