1887

Abstract

Summary

The immunogenicity of serotype suspensions inactivated by various degrees of heat exposure was examined in hamsters. No differences between leptospires killed at 50°C and at 98°C were shown. After exposure to 121°C, suspensions retained their ability to protect against lethal infections but lost their ability to prevent leptospiruria. Tests with vaccines inactivated at or below 98°C showed that the doses required for complete protection varied with the interval between vaccination and challenge. Larger doses were required to prevent the development of leptospiruria than to prevent death.

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/content/journal/jmm/10.1099/00222615-9-4-487
1976-11-01
2019-12-15
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