%0 Journal Article %A Hughes, Jane A. %A Turnbull, P. C. B. %A Stringer, M. F. %T A serotyping system for Clostridium welchii (C. perfringens) type a, and studies on the type-specific antigens %D 1976 %J Journal of Medical Microbiology, %V 9 %N 4 %P 475-485 %@ 1473-5644 %R https://doi.org/10.1099/00222615-9-4-475 %I Microbiology Society, %X Summary A serotyping scheme for Clostridium welchii (C. perfringens) type A employing 57 antisera has been used to investigate the epidemiology of 153 food-poisoning outbreaks and 32 cases of gas gangrene and other clinical infections. Respectively 65% and 59% of the isolates were typable, and in 55% of the food-poisoning outbreaks the causative serotypes were established. Isolation and reporting methods that would render the typing scheme of even greater epidemiological value are described. The type-specific antigen was shown to reside in the capsule and to be lost from strains that had become rough. Development of roughness and its prevention are described. A great range of antisera and an internationally acceptable serotyping scheme is expected after integration of this set with those developed independently in America and Japan. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-9-4-475