1887

Abstract

Summary

Tests with 140 strains representing and in a defined medium supplemented with 0·09m dimethylamine (DMA) and 0·1m potassium nitrate showed that at least 89% of the 136 strains able to reduce nitrates produced up to 9mM dimethylnitrosamine (DMN) in 70 h at 37°C. Four nitratase-negative strains produced DMN from DMA in the presence of sodium nitrate. Prolonged incubation was the most important factor in determining DMN production. Stasis and persistent infection in the urinary tract, by simulating prolonged incubation of a culture, may be of importance in determining whether the potential carcinogen, DMN, could be produced by bacterial action on DMA and nitrate in urine.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-9-2-211
1976-05-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jmm/9/2/medmicro-9-2-211.html?itemId=/content/journal/jmm/10.1099/00222615-9-2-211&mimeType=html&fmt=ahah

References

  1. Ayanaba A., Alexander M. 1973; Microbial formation of nitrosamines. in vitro Appl Microbiol 25:862
    [Google Scholar]
  2. Ayanaba A., Verstraete W., Alexander M. 1973; Possible microbial contribution to nitrosamine formation in sewage and soil. J natl Cancer Inst 50:811
    [Google Scholar]
  3. Brooks J. B., Cherry W. B., Thacker L., Alley C. C. 1972; Analysis by gas chromatography of amines and nitrosamines produced in vivo and in vitro by Proteus mirabilis. J infect Dis 126:143
    [Google Scholar]
  4. Collins-Thompson D. L., Sen N. P., Aris B., Schwinghamer L. 1972; Non- enzymic in vitro formation of nitrosamines by bacteria isolated from meat products. Can J Microbiol 18:1968
    [Google Scholar]
  5. Cowan S. T., Steel K. J. 1965; Manual for the identification of medical bacteria. London
    [Google Scholar]
  6. Fong Y. Y., Chan W. C. 1973; Bacterial production of dimethylnitrosamine in salted fish. Nature Lond 243:421
    [Google Scholar]
  7. Hawksworth G. M., Hill M. J. 1971; Bacteria and the N-nitrosation of secondary amines. Br J Cance 25:520
    [Google Scholar]
  8. Hawksworth G., Hill M. J. 1974; The in-vivo formation of N-nitrosamines in the rat bladder and their subsequent absorption. Br J Cancer 29352
    [Google Scholar]
  9. Hill M. J., Hawksworth G. 1972 Bacterial production of nitrosamines in vitro and in vivo. In N-nitroso compounds: analysis and formation. edited by P. Bogovski R. Preussmann and E. A. Walker IARC Sci. Publ. no. 3; Lyon116
    [Google Scholar]
  10. Hill M. J., Hawksworth G., Tattersall G. 1973; Bacteria, nitrosamines and cancer of the stomach. Br J Cancer 28562
    [Google Scholar]
  11. International Agency for Research on Cancer 1972 Report of the subcommittee on analytical methods for N-nitroso compounds. In N-nitroso compounds: analysis and formation. edited by P. Bogovski R. Preussmann and E. A. Walker IARC Sci. Publ. no. 3; Lyon92
    [Google Scholar]
  12. Lijinsky W. 1974; Reaction of drugs with nitrous acid as a source of carcinogenic nitrosamines. Cancer Res 34:255
    [Google Scholar]
  13. Lijinsky W., Epstein S. S. 1970; Nitrosamines as environmental carcinogens. Nature Lond 225:21
    [Google Scholar]
  14. Magee P. N. 1969; In vivo reactions of nitroso compounds. Ann N Y Acad Sci 163:717
    [Google Scholar]
  15. Miles A. A., Misra S. S., Irwin J. O. 1938; The estimation of the bactericidal power of the blood. J Hyg Camb 38:732
    [Google Scholar]
  16. Mirvish S. S. 1970; Kinetics of dimethylamine nitrosation in relation to nitrosamine carcinogenesis. J natl Cancer Inst 44:633
    [Google Scholar]
  17. Proom H., Knight B. C. J. G. 1955; The minimal nutritional requirements of some species in the genus Bacillus. J gen Microbiol 13:474
    [Google Scholar]
  18. Rowland I. R., Grasso P. 1975; Degradation of N-nitrosamines by intestinal bacteria. Appl Microbiol 29:7
    [Google Scholar]
  19. Sander J. 1968; Nitrosaminsynthese durch Bakterien. Hoppe-Seyler's Z physiol Chem 349:429
    [Google Scholar]
  20. Sander J., Schweinsberg F., Menz H. P. 1968; Untersuchungen ber üdie Entstehung cancerogener Nitrosamine im Magen. Hoppe-Seyler’s Z physiol Chem 349:429
    [Google Scholar]
  21. Sen N. P., Smith D. C., Schwinghamer L. 1969; Formation of N-nitrosamines from secondary amines and nitrite in human and animal gastric juice. Fd Cosmet Toxicol 7:301
    [Google Scholar]
  22. Thacker L., Brooks J. B. 1974; In vitro production of N-nitroso-dimethylamine and other amines by Proteus species. Infect Immun 9:648
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-9-2-211
Loading
/content/journal/jmm/10.1099/00222615-9-2-211
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error