1887

Abstract

Summary

In tests with the phagocytes of human buffy coat, a recent isolate of , which was pilated, formed small colonies and resembled the virulent Kellogg type 2 (strain BS), resisted ingestion more than did another isolate (strain AL), which was non-pilated, formed large colonies and resembled the avirulent Kellogg type 4. Some members of both strains survived for significant periods within the phagocytes in test conditions that tended to minimise rather than maximise such survival; and strain BS had a greater capacity for intracellular survival than strain AL, with some of its members surviving for at least 8 h.

Resistance to phagocytic ingestion is one important invasive mechanism of gonococci, and resistance to phagocytic digestion may also play a role in pathogenicity.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-9-1-1
1976-02-01
2022-01-23
Loading full text...

Full text loading...

/deliver/fulltext/jmm/9/1/medmicro-9-1-1.html?itemId=/content/journal/jmm/10.1099/00222615-9-1-1&mimeType=html&fmt=ahah

References

  1. Carpenter P. L. 1965; Immunology and serology, 2nd ed.. Philadelphia p 308
    [Google Scholar]
  2. Frost A. J., Smith H., Witt K., Keppbe J. 1972; The chemical basis of the virulence of Brucella abortus. X. A surface virulence factor which facilitates intracellular growth of Brucella abortus in bovine phagocytes. Br. J. exp. Path. 53:587
    [Google Scholar]
  3. Kellogg D. S. Jr, Cohen I. R., Norins L. C., Schroeter A. L., Reising G. 1968; Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 months in vitro. J. Bact.96–596
    [Google Scholar]
  4. Kellogg D. S. Jr, Peacock W. L. Jr, Deacon W. E., Brown L., Pirkle C. I. 1963; Neisseria gonorrhoeae. I. Virulence genetically linked in clonal variation. J. Bact. 85:1274
    [Google Scholar]
  5. Novotny P., Short J. A. L., Turner W. H. 1974; The relationship between gonococci and host cells: multiplication of gonococci in phagocytes of man as seen by electron microscopy and the influence of colchicine on the number of cocci obtained in infected subcutaneous chambers in guinea pigs. Proc. Soc. gen. Microbiol. 2:18
    [Google Scholar]
  6. Ofek I., Beachey E. H., Bisno A. L. 1974; Resistance of Neisseria gonorrhoeae to phagocytosis: relationship to colonial morphology and surface pili. J. infect. Dis. 129:310
    [Google Scholar]
  7. Ovcinnikov N. M., Bohenek A. A., Litvak P. B. 1934; Phagocytosis or endocytobiotics, its significance in gonorrhoea. Urologicya, Moskva 11:84
    [Google Scholar]
  8. Ovcinnikov N. M., Delektorskd V. V. 1971; Electron microscope studies of gonococci in the urethral secretions of patients with gonorrhoea. Br. J. vener, Dis. 47:419
    [Google Scholar]
  9. Punsalang A. P. Jr, Sawyer W. D. 1973; Role of pili in the virulence of Neisseria gonorrhoeae. Infect. Immun. 8:255
    [Google Scholar]
  10. Smith H. 1968; Biochemical challenge of microbial pathogenicity. Bact. Rev. 32:164
    [Google Scholar]
  11. Smith H. 1974; Gonococcal resistance to ingestion and digestion by human phagocytes. Proc. Soc. gen. Microbiol. 1:76
    [Google Scholar]
  12. Smith H. 1975; Microbial interference with host defence mechanisms. Monogr. Allergy9–13
    [Google Scholar]
  13. Spink W. W., Keefer C. S. 1937; Studies of gonococcal infection. I. A study of the mode of destruction of the gonococcus in vitro. J. clin. Invest. 16:169
    [Google Scholar]
  14. Thomas D. W., Hill J. C., Tyeryar F. J. Jr 1973; Interaction of gonococci with phagocytic leukocytes from men and mice. Infect. Immun. 8:98
    [Google Scholar]
  15. Thongthai C., Sawyer W. D. 1973; Studies on the virulence of Neisseria gonorrhoeae. I. Relation of colonial morphology and resistance to phagocytosis by polymorphonuclear leucocytes. Infect. Immun. 7:373
    [Google Scholar]
  16. Veale D. R., Smith H., Witt K., Marshall R. B. 1975; Differential ability of colonial types of Neisseria gonorrhoeae to produce infection and an inflammatory response in subcutaneous perforated plastic chambers in guinea-pigs and rabbits. J. med. Microbiol. 8:325
    [Google Scholar]
  17. Ward M. E., Glynn A. A., Watt P. J. 1972; The fate of gonococci in polymorphonuclear leucocytes: an electron microscopic study of the natural disease. Br. J. exp. Path. 53:289
    [Google Scholar]
  18. Watt P. J. 1970; The fate of gonococci in polymorphonuclear leucocytes. J. med. Microbiol. 3:501
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-9-1-1
Loading
/content/journal/jmm/10.1099/00222615-9-1-1
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error