1887

Abstract

SUMMARY

Production of β-lactamase by 15 strains of has been investigated. All the strains produce a constitutive β-lactamase, which readily hydrolyses penicillin G, ampicillin, and cephaloridine. The β-lactamase produced by these strains is indistinguishable from the type-IIIa enzyme commonly found in strains of . The β-lactamase gene has been transferred from the enzyme-producing strains of to strains of and a strain of .

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-8-3-437
1975-08-01
2024-12-05
Loading full text...

Full text loading...

/deliver/fulltext/jmm/8/3/medmicro-8-3-437.html?itemId=/content/journal/jmm/10.1099/00222615-8-3-437&mimeType=html&fmt=ahah

References

  1. Awdeh Z. L., Williamson A. R., Askonas B. A. 1968; Isoelectric focusing in polyacrylamide gel and its application to immunoglobulins. Nature, Lond 219:66
    [Google Scholar]
  2. Datta N., Richmond M. H. 1966; The purification and properties of a penicillinase whose synthesis is mediated by an r factor in Escherichia coli. Biochem. J 98:204
    [Google Scholar]
  3. Egawa R., Sawai T., Mitsuhashi S. 1967; Drug resistance of enteric bacteria. XII. Unique substrate specificity of penicillinase produced by R factors. Jap. J. Microbiol 11:173
    [Google Scholar]
  4. Khan W., Ross S., Rodriguez W., Controni G., Saz A. K. 1974; Haemophilus influenzae type B resistant to ampicillin. Report of two cases. J. Am. med. Ass 229:298
    [Google Scholar]
  5. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. 1951; Protein measurement with the Folin phenol reagent. J. biol. Chem 193:265
    [Google Scholar]
  6. Novick P. R. 1962; STAPHYLOCOCCAL penicillinase and the new penicillins. Biochem. J 83:229
    [Google Scholar]
  7. O’Callaghan C. H., Morris A., Kirby S., Shingler A. H. 1972; Novel method for detection of β-lactamases by using a chromogenic cephalosporin substrate. Antimicrob. Agents Chemother 1:283
    [Google Scholar]
  8. Perret C. J. 1954; Iodometric assay of penicillinase. Nature, Lond 174:1012
    [Google Scholar]
  9. Richmond M. H., Sykes R. B. 1973; The β -lactamases of Gram-negative bacteria andtheir possible physiological role. Adv. Microb. Physiol 9:31
    [Google Scholar]
  10. Salaman M. R., Williamson A. R. 1971; Isoelectric focusing of proteins in the native and denatured states. Biochem. J 122:93
    [Google Scholar]
  11. Sykes R. B., Richmond M. H. 1970; Intergeneric transfer of /Mactamase gene between Pseudomonas aeruginosa and Escherichia coli. Nature, Lond 226:952
    [Google Scholar]
  12. Sykes R. B., Grinsted J., Ingram L. C., Saunders J. R., Richmond M. H. 1972; Some properties of R factors isolated from Pseudomonas aeruginosa. In Bacterial plasmids and antibiotic resistance edited by Krcmery V., Rosival L., Watanabe T. Berlin: p 27
    [Google Scholar]
  13. Williams J. D., Cavanagh P. 1974; Ampicillin resistant Haemophilus influenzae meningitis. Lancet 1:864
    [Google Scholar]
/content/journal/jmm/10.1099/00222615-8-3-437
Loading
/content/journal/jmm/10.1099/00222615-8-3-437
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error