THE NUCLEAR DEHYDROGENATION OF STEROIDS BY INTESTINAL BACTERIA Free

Abstract

SUMMARY

We have postulated that bacteria able to dehydrogenate the bile-acid nucleus are important in the aetiology of cancer of the colon. In this paper we report on screening for the ability to carry out two such reactions. The relevant enzymes are produced by a high proportion of strains of and by small numbers of strains in other clostridial species, but not by organisms of the other genera tested. Strains able to dehydrogenate the bile-acid nucleus represent a high proportion of the lecithinase-negative clostridia isolated from faeces of people living in Britain but a low proportion of those from people living in Uganda or Hong Kong.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-8-3-429
1975-08-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jmm/8/3/medmicro-8-3-429.html?itemId=/content/journal/jmm/10.1099/00222615-8-3-429&mimeType=html&fmt=ahah

References

  1. Aries V. C., Crowther J. S., Drasar B. S., Hill M. J., Williams R. E. O. 1969; Bacteria and the aetiology of cancer of the large bowel. Gut 10:334
    [Google Scholar]
  2. Aries V. C., Goddard P., Hill M. J. 1971; Degradation of steroids by intestinal bacteria. III. 3-oxo-5ß-steroid △1 dehydrogenase and 3-oxo-5ß-steroid △4 dehydrogenase. Biochim. biophys. Acta 248:482
    [Google Scholar]
  3. Cowan S. T., Steel K. J. 1965 Manual for the identification of medical bacteria London:
    [Google Scholar]
  4. Drasar B. S., Crowther J. S. 1970; The cultivation of human intestinal bacteria. In Isolation of anaerobes, Soc. appl. Bact. Tech Ser. no. 5, edited by Shapton D. A., Board R. G. London: p 93
    [Google Scholar]
  5. Drasar B. S., Goddard P., Heaton S., Peach S., West B. 1976; Clostrida isolated from faeces. J. med. Microbiol 9: in press
    [Google Scholar]
  6. Goddard P., Hill M. J. 1972; Degradation of steroids by intestinal bacteria. IV. The aromatisation of ring A. Biochim. biophys. Acta 280:336
    [Google Scholar]
  7. Goddard P., Hill M. J. 1973; The dehydrogenation of the steroid nucleus by human gut bacteria. Biochem. Soc. Trans 1:1113
    [Google Scholar]
  8. Hill M. J. 1971; Gut bacteria, steroids and cancer of the large bowel. In Some implications of steroid hormones in cancer edited by Williams D. C., Briggs M. H. London: p 94
    [Google Scholar]
  9. Hill M. J., Drasar B. S., Aries V., Crowther J. S., Hawksworth G., Williams R. E. O. 1971; Bacteria and aetiology of cancer of the large bowel. Lancet 1:95
    [Google Scholar]
  10. Hill M. J., Hawksworth G. M. 1972; Bacterial production of nitrosamines in vitro and in vivo. In N-nitroso compounds analysis and formation, IARC Sci. Pub no. 3, edited by Bogovski P. Preussman R., Walker E. A. Lyons: p 116
    [Google Scholar]
  11. Holdeman L. V., Moore W. E. C. (Editors) 1972 Anaerobe laboratory manual Blacksburg, Virginia:
    [Google Scholar]
  12. Peach S., Fernandez F., Johnson K., Drasar B. S. 1974; The non-sporing anaerobic bacteria in human faeces. J. med. Microbiol 7:213
    [Google Scholar]
  13. Sehgal S. N., Vezina C. 1970; Microbial aromatisation of steroids into equilin. Appl. Microbiol 20:875
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-8-3-429
Loading
/content/journal/jmm/10.1099/00222615-8-3-429
Loading

Data & Media loading...

Most cited Most Cited RSS feed