1887

Abstract

Summary

The induction of L-forms of by penicillin, amoxycillin and glycine has been studied on a nutrient-agar medium. The minimal inducing concentrations of the antibiotics were generally the same as their minimal inhibitory concentrations, but the addition of a sub-inducing concentration of glycine lowered the minimal inducing concentration of penicillin.

Preliminary observations have shown that L-forms are induced by penicillin or amoxycillin on a medium in which mucoid sputum forms the sole source of nutrients, and that they remain viable for at least 48 h in the absence of added osmotic stabiliser. The minimal inducing concentration on “sputum agar” is within the range of concentrations measured in sputum from patients receiving amoxycillin therapy.

The implications of these observations in relation to bactericidal therapy of haemophilus infections of the respiratory tract are discussed.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-8-2-369
1975-05-01
2019-11-21
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-8-2-369
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error