1887

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Volume 8, Issue 2

DIFFERENTIAL ABILITY OF COLONIAL TYPES OF TO PRODUCE INFECTION AND AN INFLAMMATORY RESPONSE IN SUBCUTANEOUS PERFORATED PLASTIC CHAMBERS IN GUINEA-PIGS AND RABBITS Free

Abstract

SUMMARY

Perforated plastic chambers implanted subcutaneously in guinea-pigs and rabbits became encapsulated and filled with sterile transudate. When these chambers in guinea-pigs were inoculated with various strains of , persistent infections were achieved without the use of anti-inflammation agents and in the presence of a substantial predominantly polymorphonuclear inflammatory response. Two strains with small colonies similar to types 1 and 2, and one strain with large colonies similar to type 4 of Kellog ., (1963 and 1968), showed differences in infectivity comparable with those that might be expected in man, and passage through guinea-pig chambers increased this infectivity. Rabbit chambers could not be infected without the use of an anti-inflammation drug (betamethasone), and differences in infectivity between strains were not as clear cut. The growth of in chambers in the guinea-pig provides a convenient model system for studying some aspects of the pathogenicity of this organism.

  • Received:
  • Accepted:
  • Published Online:
© J. MED. MICROBIOL. 1975
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1975-05-01
2024-04-19
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DIFFERENTIAL ABILITY OF COLONIAL TYPES OF NEISSERIA GONORRHOEAE TO PRODUCE INFECTION AND AN INFLAMMATORY RESPONSE IN SUBCUTANEOUS PERFORATED PLASTIC CHAMBERS IN GUINEA-PIGS AND RABBITS
J. Med. Microbiol. 8, 325 (1975); https://doi.org/10.1099/00222615-8-2-325
/content/journal/jmm/10.1099/00222615-8-2-325
/content/journal/jmm/10.1099/00222615-8-2-325
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