1887

Abstract

SUMMARY

A strain of has been isolated from a hospital environment over 3 months. Every isolate was lysed by phage 77, had high-level resistance to streptomycin, and was resistant to about 250 pg per ml of both tetracycline and sulphonamide; a combination of sulphamethoxazole and trimethoprim produced little bacteristatic synergy towards each isolate. All these organisms were thus considered to be “the same” the variation in other properties was probably due to rapid evolutionary change . The variation in sensitivity to methicillin and neomycin, and the absence of penicillinase production in some isolates, probably indicated loss of the relevant genes. Several isolates had probably acquired resistance to lincomycin by a one-step mutation . The usefulness of lincomycin and analogues in treating staphylococcal infections seems limited.

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/content/journal/jmm/10.1099/00222615-8-1-39
1975-02-01
2022-01-25
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References

  1. Duncan I. B. R. 1968; Development of lincomycin resistance by staphylococci. Antimicrob. Agents Chemother. 1967 p 723
    [Google Scholar]
  2. Grinsted J., Lacey R. W. 1973; Genetic variation of streptomycin resistance in clinical strains of Staphylococcus aureus. J. med. Microbiol 6:351
    [Google Scholar]
  3. Lacey R. W. 1972; Genetic control in methicillin-resistant strains of Staphylococcus aureus. J. med. Microbiol 5:497
    [Google Scholar]
  4. Lacey R. W. 1974; Can methicillin-resistant strains of Staphylococcus aureus be treated with methicillin?. Lancet 1:88
    [Google Scholar]
  5. Lacey R. W., Chopra I. 1972; Evidence for mutation to streptomycin resistance in clinical strains of Staphylococcus aureus. J. gen. Microbiol 73:175
    [Google Scholar]
  6. Lacey R. W., Chopra I. 1974; Genetic studies of a multi-resistant strain of Staphylococcus aureus. J. med. Microbiol 7:285
    [Google Scholar]
  7. Lacey R. W., Grinsted J. 1973; Genetic analysis of methicillin-resistant strains of Staphylococcus aureus’, evidence for their evolution from a single clone. J. med. Microbiol 6:511
    [Google Scholar]
  8. Lacey R. W., Lewis E., Grinsted J. 1973; Loss of antibiotic resistance in Staphylococcus aureus in vivo probably resulting from cloxacillin therapy. J. med. Microbiol 6:191
    [Google Scholar]
  9. Lacey R. W., Lewis E. L., Rosdahl V. T. 1974; Evolution of plasmids in vivo in a strain of Staphylococcus aureus. J. med. Microbiol 7:117
    [Google Scholar]
  10. Lacey R. W., Rosdahl V. T. 1974; An unusual “penicillinase plasmid ” in Staphylococcus aureus; evidence for its transfer under natural conditions. J. med. Microbiol 7:1
    [Google Scholar]
  11. Lewis E. L., Lacey R. W. 1973; Present significance of resistance to trimethoprim and sulphonamides in coliforms, Staphylococcus aureus and Streptococcus faecalis. J. clin. Path 26:175
    [Google Scholar]
  12. McGehee R. F., Barre F. F., Finland M. 1969; Resistance of Staphylococcus aureus to lincomycin, Clinimycin and erythromycin. Antimicrob. Agents Chemother 1968: p 392
    [Google Scholar]
  13. Rubin S. J., Rosenblum E. D. 1971; Effects of the recipient strain and ultraviolet irradiation on transduction kinetics of the penicillinase plasmid of Staphylococcus aureus. J. Bact 108:1192
    [Google Scholar]
  14. Williams R. E. O., Rippon J. E. 1952; Bacteriophage typing of Staphyloccus aureus. J. Hyg., Camb 50:320
    [Google Scholar]
  15. Wright C. L. T., Harper J. 1970; Fusidic acid and lincomycin therapy in staphylococcal infections in cystic fibrosis. Lancet 1:9
    [Google Scholar]
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