RT Journal Article SR Electronic(1) A1 Hewitt, J. H. A1 Sanderson, P. J.YR 1974 T1 The Effect of Methicillin on Skin Lesions in Guinea-Pigs Caused By “Methicillin-Sensitive” and “Methicillin-Resistant” Staphylococcus Aureus JF Journal of Medical Microbiology, VO 7 IS 2 SP 223 OP 235 DO https://doi.org/10.1099/00222615-7-2-223 PB Microbiology Society, SN 1473-5644, AB SUMMARY The therapeutic effect of methicillin on skin lesions in guinea-pigs produced by two strains of Staphylococcus aureus showing heterogeneous resistance to methicillin, and by two strains of normal sensitivity, was compared. Methicillin was given intravenously immediately after the intradermal inoculation of staphylococci and the skin lesions were measured 24 hours later. The serum concentrations of methicillin were comparable to those obtained in man with standard dosage and were below or similar to the MIC of the “resistant” staphylococci when this was determined at 37°C. No difference was found after methicillin administration in the size of lesions produced by “resistant” and “sensitive” staphylococci., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-7-2-223