1887

Abstract

SUMMARY

The therapeutic effect of methicillin on skin lesions in guinea-pigs produced by two strains of showing heterogeneous resistance to methicillin, and by two strains of normal sensitivity, was compared. Methicillin was given intravenously immediately after the intradermal inoculation of staphylococci and the skin lesions were measured 24 hours later. The serum concentrations of methicillin were comparable to those obtained in man with standard dosage and were below or similar to the MIC of the “resistant” staphylococci when this was determined at 37°C. No difference was found after methicillin administration in the size of lesions produced by “resistant” and “sensitive” staphylococci.

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1974-05-01
2021-10-23
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