1887

Abstract

SUMMARY

The therapeutic effect of methicillin on skin lesions in guinea-pigs produced by two strains of showing heterogeneous resistance to methicillin, and by two strains of normal sensitivity, was compared. Methicillin was given intravenously immediately after the intradermal inoculation of staphylococci and the skin lesions were measured 24 hours later. The serum concentrations of methicillin were comparable to those obtained in man with standard dosage and were below or similar to the MIC of the “resistant” staphylococci when this was determined at 37°C. No difference was found after methicillin administration in the size of lesions produced by “resistant” and “sensitive” staphylococci.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-7-2-223
1974-05-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jmm/7/2/medmicro-7-2-223.html?itemId=/content/journal/jmm/10.1099/00222615-7-2-223&mimeType=html&fmt=ahah

References

  1. Ancill R. J. 1956; The blood volume of the normal guinea-pig. J. Physiol 132:469
    [Google Scholar]
  2. Annear D. I. 1968; The effect of temperature on resistance of Staphylococcus aureus to methicillin and some other antibiotics. Med. J. Aust 1:444
    [Google Scholar]
  3. Bastin R., Worms R., Acar J. F. 1967; Traduction clinique de la résistance hétérogène des staphylocoques aux pénicillines et céphalosporines. Path. Biol., Paris 15:1205
    [Google Scholar]
  4. Benner E. J., Kayser F. H. 1968; Growing clinical significance of methicillin-resistant Staphylococcus aureus. Lancet 2:741
    [Google Scholar]
  5. Bulger R. J., Feigl P., Nielson K. 1972; Comparison of treatments with several antibiotics in experimental infections due to methicillin-resistant Staphylococcus aureus. J. infect. Dis 126:674
    [Google Scholar]
  6. Burke J. 1961; The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery, St Louis 50:161
    [Google Scholar]
  7. Chabbert Y. A. 1970; Detection of methicillin and cephalothin resistant staphylococci. In The control of chemotherapy, edited by P. J. Watt London: p 17
    [Google Scholar]
  8. Chabbert Y. A., Baudens J. G., Acar J. F., Gerbaud G. R. 1965; La résistance naturelle des staphylocoques á la méthicilline et l’oxacilline. Revue fr. Etud. clin. Biol 10:495
    [Google Scholar]
  9. Eriksen K. R., Erichsen I. 1964; Resistance to methicillin, isoxazolyl penicillins and cephalothin in Staphylococcus aureus. Acta path, microbiol. scand 62:255
    [Google Scholar]
  10. Harding J. W. 1963; Infections due to methicillin-resistant strains of Staphylococcus pyogenes. J. clin. Path 16:268
    [Google Scholar]
  11. Harris D. M. 1970; Clinical implications of methicillin-resistance in Staphylococcus aureus. Guy′s Hosp. Rep 119:145
    [Google Scholar]
  12. Hewitt J. H. 1971; Antibiotic sensitivity testing. Br. med. J 2:248
    [Google Scholar]
  13. Hewitt J. H., Coe A. W., Parker M. T. 1969; The detection of methicillin resistance in Staphylococcus aureus. J. med. Microbiol 2:443
    [Google Scholar]
  14. Hewitt J. H., Parker M. T. 1968; Sensitivity of penicillinase-forming strains of Staphylococcus aureus and of their penicillinase-negative variants to cephaloridine, cephalothin, methicillin, and benzylpenicillin. J. clin. Path 21:75
    [Google Scholar]
  15. Jevons M. P. 1961; “Celbenin”-resistant Staphylococci. Br. med. J 1:124
    [Google Scholar]
  16. Knox R. 1961; “Celbenin”-resistant Staphylococci. Br. med. J 1:126
    [Google Scholar]
  17. Knudsen E. T., Rolinson G. N. 1960; Absorption and excretion of a new antibiotic (BRL 1241). Br. med. J 2:700
    [Google Scholar]
  18. Miles A. A., Miles E. M., Burke J. 1957; The value and duration of defence reactions of the skin to the primary lodgement of bacteria. Br. J. exp. Path 38:79
    [Google Scholar]
  19. Miles A. A., Misra S. S., Irwin J. O. 1938; The estimation of the bactericidal power of the blood. J. Hyg., Camb 38:732
    [Google Scholar]
  20. Parker M. T., Hewitt J. H. 1970; Methicillin resistance in Staphylococcus aureus. Lancet 1:800
    [Google Scholar]
  21. Paterson J. S. 1967; In Universities Federation for Animal Welfare: handbook on the care and management of laboratory animals. 3rd ed London p 241
    [Google Scholar]
  22. Short D. J., Woodnott D. P. (Editors) 1969; Institute of Animal Technicians: Manual of laboratory animal practice and techniques. 2nd ed London p 71
    [Google Scholar]
  23. Siboni K., Krogh L. 1968; The sensitivity to methicillin and penicillin of methicillin-resistant strains of Staphylococcus aureus. Acta path, microbiol. scand 74:381
    [Google Scholar]
  24. Smith J. T., Hamilton-Miller J. M. T., Knox R. 1969; Bacterial resistance to penicillins and cephalosporins. J. Pharm. Pharmac 21:337
    [Google Scholar]
  25. Stewart G. T., Holt R. J. 1963; Evolution of natural resistance to the newer penicillins. Br. med. J 1:308
    [Google Scholar]
  26. Sutherland R., Rolinson G. N. 1964; Characteristics of methicillin-resistant staphylococci. J. Bact 87:887
    [Google Scholar]
  27. Turner G. C., Cox P. E. 1967; Resistance to cloxacillin among hospital staphylococci. J. clin. Path 20:870
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-7-2-223
Loading
/content/journal/jmm/10.1099/00222615-7-2-223
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error