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A plasmid (PF) has been identified in 18 strains of Staphylococcus aureus that belong to phage-groups I, II, and III or are non-typable. This plasmid is characterised by: (a) carrying the genes for resistance to fusidic acid and cadmium ions, but not to arsenate or mercury ions, and for the production of D-serotype penicillinase, (b) A molecular weight of 16 million daltons, (c) the ability to exist with a “penicillinase plasmid” of compatibility-group I, and (d) a tendency to fragment. The PF plasmid has probably spread among the natural population of staphylococci.
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