RT Journal Article SR Electronic(1) A1 Grinsted, J. A1 Lacey, R. W.YR 1973 T1 Genetic Variation of Streptomycin Resistance in Clinical Strains of Staphylococcus Aureus JF Journal of Medical Microbiology, VO 6 IS 3 SP 351 OP 361 DO https://doi.org/10.1099/00222615-6-3-351 PB Microbiology Society, SN 1473-5644, AB SUMMARY Of 74 distinct strains of Staphylococcus aureus obtained from clinical sources, about 70 per cent. were resistant to high levels of streptomycin (MIC>1 mg per ml) and 30 per cent. resistant to lower levels (MIC about 100 μg per ml). Streptomycin resistance in four strains exhibiting high-level resistance was stable on storage, whilst that in four strains with low-level resistance was unstable. Three of the latter were also resistant to other antibiotics; these resistances were also unstable, and in one of these strains (FAR4) there was evidence that streptomycin resistance was linked to erythromycin and neomycin resistance and to production of δ-haemolysin. Strain 649 is resistant only to streptomycin (low-level resistance); plasmid DNA with a molecular weight of about 38 million daltons corresponding to this resistance was isolated from this strain. Attempts to correlate the CCC-DNA from the multi-resistant strain FAR4 with its resistances were unsuccessful. Resistance to spectinomycin was not associated with resistance to streptomycin, but with erythromycin resistance or with neomycin resistance., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-6-3-351