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Amongst 778 yeasts isolated from clinical specimens and tested for sensitivity to 5-fluorocytosine, 4.1 per cent. had minimum inhibitory concentrations of 31 μg of 5FC per ml, or more, a lower percentage of primary resistance than in some reported series. Resistance was found in 4.5 per cent. of Candida albicans, 0.7 per cent. of Torulopsis glabrata and 5.6 per cent. of Cand. tropicalis. The minimum fungicidal concentrations for the resistant candida isolates greatly exceeded the minimum inhibitory concentrations, and some yeasts with low minimum inhibitory concentrations contained small numbers of highly resistant organisms.
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