1887

Abstract

SUMMARY

Groups of rabbits were given intratracheal injections of 5 x 10 or 10 yeast-forms of . Morphological transformation from yeasts to mycelia was seen in the tissues within 1 hr of injection. The lungs showed an intense cellular reaction with formation of bronchopneumonia, but this quickly and completely resolved and no progressive lesion developed. Rabbit lung seemed to be highly resistant to infection.

Fungus entered the blood from the lungs and was disseminated to other viscera. Mycelial forms invaded polymorphonuclear leucocytes, large monocytes, blood vessels and renal tubular epithelium. Proliferation of large monocytes was responsible for fragmentation and destruction of the fungus in all the tissues except the spleen, where there was complete absence of reaction although fungal cultures were positive. The fungus was finally excreted by the kidney in which cortical abscesses developed. These healed slowly by scarring with occasional granuloma formation.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-6-3-287
1973-08-01
2022-01-23
Loading full text...

Full text loading...

/deliver/fulltext/jmm/6/3/medmicro-6-3-287.html?itemId=/content/journal/jmm/10.1099/00222615-6-3-287&mimeType=html&fmt=ahah

References

  1. Ajello L., George L. K., Kaplan W., Kaufman L. 1963; Laboratory manual for medical mycology (U,. S. Dept, of Health, Education and Welfare). Atlanta, Georgia
    [Google Scholar]
  2. Aoyama S., Ata S. 1961; Studies on candidiasis in Japan. (Education Ministry of Japan) p 115
    [Google Scholar]
  3. Chakravarty S. C., Damodaran V. N., Sandhu R. S. 1966; Effect of hyaluronidase in experimental candidiasis with special reference to lung lesions. Mycopath. My col. appl 30:287
    [Google Scholar]
  4. Chitale A. R., Bhende Y. M. 1965; Experimental moniliasis in rabbits and mice. Indian J. Path. Bact 8:89
    [Google Scholar]
  5. Damodaran V. N., Chakravarty S. C. 1964; Experimental candidiasis in mice. The effect of hyaluronidase on the production of lesions with particular reference to lungs. Indian J. Chest Dis 6:19
    [Google Scholar]
  6. Evans W. E. D., Winner H. I. 1954; The histogenesis of lesions in experimental moniliasis in rabbits. J. Path. Bact 67:531
    [Google Scholar]
  7. Felisati D., Bastianini L., De Mitri T. 1959; Antibiotics and Candida albicans given by endo-bronchial route. Antibiotics Chemother 9:744
    [Google Scholar]
  8. Gresham G. A., Burns M. 1960; Tissue invasion in Candida. In Progress in biological science in relation to dermatology edited by Rook A. London: p 174
    [Google Scholar]
  9. Hill D. W., Gebhardt L. P. 1956; Morphological transformation of Candida albicans in tissues of mice. Proc. Soc. Exp. Biol. Med 92:640
    [Google Scholar]
  10. Kurotchkin T. J., Lim C. E. 1933; Experimental broncho-moniliasis in sensitized rabbits. Proc. Soc. Exp. Biol. Med 31:332
    [Google Scholar]
  11. Louria D. B., Fallon Nancy, Browne H. G. 1960; The influence of cortisone on experimental fungus infections in mice. J. Clin. Invest 39:1435
    [Google Scholar]
  12. Nickerson W. J., Edwards G. A. 1949; Studies on the physiological basis of morphogenesis in fungi. 1. The respiratory metabolism of dimorphic pathogenic fungi. J. Gen. Physiol 33:41
    [Google Scholar]
  13. O’Grady F., Pennington J. H., Stansfield A. G. 1967; Delayed hypersensitivity in mouse thigh candidosis. Br. J. Exp. Path 48:196
    [Google Scholar]
  14. Scherr G. H. 1951; Studies of the dimorphism mechanism in Saccharomyces cereviseae. My copath. My col. appl 6:182
    [Google Scholar]
  15. Winner H. I. 1960; Experimental moniliasis in guinea pigs. J. Path. Bact 79:420
    [Google Scholar]
  16. Young G. 1958; The process of invasion and persistence of Candida albicans injected intraperitoneally into mice. J. Infect. Dis 102:114
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-6-3-287
Loading
/content/journal/jmm/10.1099/00222615-6-3-287
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error