After being given tetracycline in drinking water (0·1 per cent.) for 5 days, rats were inoculated orally with on three occasions at 2-day intervals. Immediately after the first inoculation, the concentration of tetracycline in the water was reduced to 0·01 per cent. and this was maintained for the next 28 days. The rats' mouths were regularly colonised by , the organism being recoverable throughout the experiment. Histological examination showed the organism in the tissues in 75 per cent. of the animals. Infection of the dorsal surface of the tongue produced a striking change in the histological appearance of the lingual epithelium, reminiscent of that found in candidal leukoplakia in man.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error