1887

Abstract

SUMMARY

The minimum inhibitory concentration of six antibiotics for ten clinical isolates of was determined. One of the isolates, which was unusually resistant to ampicillin and cephaloridine, possessed an intracellular β-lactamase. This enzyme, which was more active against cephaloridine than against the penicillins, was characterised. No β-lactamase activity could be detected in any of the moderately resistant strains, or in whole-cell preparations, or culture filtrates. The production of β-lactamase was not induced in resistant or sensitive strains by growth in media containing ampicillin.

The above evidence supports the view that strains of that are highly resistant to β-lactam antibiotics owe this property to the presence of an intracellular β-lactamase.

Attempts to transfer antibiotic resistance from and vice versa, and from one strain of to another, were unsuccessful.

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/content/journal/jmm/10.1099/00222615-6-2-201
1973-05-01
2022-05-29
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