Counts of antigen-reactive cells, obtained by means of the Jerne plaque and rosette techniques, in mice primed with sheep red cells, showed an initial fall after challenge with sheep red cells. To obtain this result, the challenge dose had to be relatively large and to be given at a sufficient interval of time after priming. The reduction in the numbers of antigen-reactive cells is mediated by a soluble substance released in consequence of the interaction of antigen and antigen-reactive cells. The activity of this substance is not restricted to the specific system that led to its formation, since a fall in the count of antigen-reactive cells of a different specificity could be demonstrated in mice primed with two antigens. Though not characterised, the substance responsible for this effect is probably a “lymphokine” possessing cytotoxic activity.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error