Two strains of Staphylococcus aureus that have linked and unstable resistance to kanamycin andstreptomycin have been isolated. It was shown that in oneof these strains (1) resistance to kanamycin and streptomycin was co-ordinately lost at highfrequency during nineserial screenings of resistant variants, (2) resistance toboth antibiotics could beco-transduced, and (3) in the transductants, resistance to these antibiotics was both linked and unstable,as in the donor strain. In both strains resistance tostreptomycin and kanamycin appears to be controlled by the same extrachromosomal element.
AnnearD. I.,
GrubbW. B.1969; Spontaneous loss of resistance to kanamycin and other antibiotics in methicillin-resistant cultures of Staphylococcus aureus. Med. J. Aust 2:902
AnnearD. I.,
GrubbW. B.1972; Linked and unstable resistance to kanamycin and penicillin, and diffusible pigment production, in an isolate of Staphylococcus aureus. J. Med. Microbiol 5:109
ChabbertY. A.,
BaudensJ. G.,
GerbaudG. R.1964; Variations due to acriflavin and transduction of resistance to kanamycin and chloramphenicol in staphylococci. Annis Inst. Pasteur, Paris 107:678 (in French)
EvansR. J.,
WaterworthPamela M.1966; Naturally-occurring fusidic acid resistance in staphylococci and its linkage to other resistances. J. Clin. Path 19:555
MitsuhashiS.,
HashimotoH.,
KonoM.,
MorimuraM.1965; Drug resistance of staphylococci. II. Joint elimination and joint transduction of the determinants of penicillinase production and resistance to macrolide antibiotics. J. Bact 89:988