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Cultures of Escherichia coli of human and animal origin were ingested by three normal persons. It was easy to produce temporary colonisation of the bowel by strains from both sources. Considerable variation in duration of carriage was observed. Some of the results were compatible with the view that colicines determined the fate of ingested strains. In other instances, however, colicines were ineffective in vivo although activity could be demonstrated in vitro.
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