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Volume 5, Issue 3

Action Of Ethylenediaminetetra-Acetic Acid (Edta) On Carbenicillin-Resistant Strains Of Free

Abstract

Summary

Sub-inhibitory concentrations of EDTA reduce the resistance of strains of to carbenicillin . With strains made resistant by habituation, the extent of the reduction of carbenicillin resistance produced by a fixed subinhibitory dose of EDTA (200 μg per ml) did not vary with the degree of resistance even though the development of this habituated resistance was associated with a loss of sensitivity of the bacterial cells to EDTA. This suggests (1) that the reduction of habituated carbenicillin resistance by EDTA is due to a synergistic effect of the EDTA-carbenicillin combination, and (2) that the development of habituated carbenicillin resistance in is due to a change in type or amount, or in both, of cell-wall lipopolysaccharide.

In carbenicillinase-producing resistant strains of , the amount of reduction of carbenicillin resistance by EDTA is variable and appears to be inversely related to the quantity of carbenicillinase produced by the bacterial strain.

  • Received:
  • Accepted:
  • Published Online:
© Society for General Microbiology, 1972
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1972-08-01
2024-12-08
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Action Of Ethylenediaminetetra-Acetic Acid (Edta) On Carbenicillin-Resistant Strains Of Pseudomonas Aeruginosa
J. Med. Microbiol. 5, 355 (1972); https://doi.org/10.1099/00222615-5-3-355
/content/journal/jmm/10.1099/00222615-5-3-355
/content/journal/jmm/10.1099/00222615-5-3-355
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