1887

Abstract

Summary

Piglets immediately after normal birth were removed from their mothers and given antisera by mouth and then infected, also by mouth, with an enteropathogenic strain of (O141: K85ab,88ab) mixed with larger numbers of a non-pathogenic strain and lactobacilli.

When antisera prepared against live, heat-killed or methanol-killed organisms of the O141: K85ab,88ab strain were used, the onset of diarrhoea was delayed or prevented. Antisera prepared against porcine enteropathogenic strains not possessing any of the O or K antigens of O141: K85ab,88ab had little effect. So did antiserum against K12 to which the plasmid responsible for porcine enterotoxin production (Ent) had been transmitted. Antiserum prepared against an enteropathogenic strain O8: K87,88ab had a definite controlling effect, the effect apparently being due to the K88ab antigen common to this strain and the infecting O141: K85ab,88ab strain.

Antisera administered subcutaneously also had a controlling effect on experimental diarrhoea, but their effect was markedly less than that of the same sera given orally.

Only low concentrations of enteropathogenic organisms were found in the contents of the small intestine of piglets in which the diarrhoea was controlled by antiserum, indicating that antibacterial antibody was important in his respect.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-5-3-345
1972-08-01
2022-01-26
Loading full text...

Full text loading...

/deliver/fulltext/jmm/5/3/medmicro-5-3-345.html?itemId=/content/journal/jmm/10.1099/00222615-5-3-345&mimeType=html&fmt=ahah

References

  1. Kohler E. M. 1967; Studies of Escherichia coli in gnotobiotic pigs. V. Evaluation of the effects of oral and parenteral administration of immune serum. Canad. J. Comp. Med 31:283
    [Google Scholar]
  2. Kohler E. M., Bohl E. H. 1966; Studies of Escherichia coli in gnotobiotic pigs. III. Evaluation of orally administered specific antisera. Canad. J. Comp. Med 30:233
    [Google Scholar]
  3. Miniats O. P., Mitchell L., Barnum D. A. 1970; Response of gnotobiotic pigs to Escherichia coli. Canad. J. Comp. Med 34:269
    [Google Scholar]
  4. Rogosa M., Mitchell Joyce A., Wiseman R. F. 1951; A selective medium for the isolation and enumeration of oral and fecal lactobacilli. J. Bact 62:132
    [Google Scholar]
  5. Smith H. W., Gyles C. L. 1970; The relationship between two apparently different enterotoxins produced by enteropathogenic strains of Escherichia coli of porcine origin. J. Med. Microbiol 3:387
    [Google Scholar]
  6. Smith H. W., Linggood Margaret A. 1971a; Observations on the pathogenic properties of the K88, Hly and Ent plasmids of Escherichia coli with particular reference to porcine diarrhoea. J. Med. Microbiol 4:467
    [Google Scholar]
  7. Smith H. W., Linggood Margaret A. 1971b; The effect of antisera in protecting pigs against experimental Escherichia coli diarrhoea and oedema disease. J. Med. Microbiol. 4:487
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-5-3-345
Loading
/content/journal/jmm/10.1099/00222615-5-3-345
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error