The pathogenic avian mycoplasma caused a 50 per cent. reduction of ciliary activity in chicken tracheal organ cultures after 4–5 days. Nine days were required for a similar loss of activity when the non-pathogenic mycoplasma was introduced into the cultures 24 to 48 hr before . The protective effect occurred only with viable organisms and did not involve inhibition of the growth of . The phenomenon was observed with most strains of and all strains of tested. A single strain of failed to protect the ciliary activity of -infected cultures. Chicken tracheal organ cultures infected with alone showed more prolonged ciliary activity than cultures uninfected with any mycoplasma. The possible reasons for these phenomena are discussed.


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