@article{mbs:/content/journal/jmm/10.1099/00222615-5-1-67, author = "Stewart-Tull, D. E. S. and Armstrong, Ann V.", title = "The Effect Of 1-Hydroxyphenazine And Pyocyanin From Pseudomonas Aeruginosa On Mammalian Cell Respiration", journal= "Journal of Medical Microbiology", year = "1972", volume = "5", number = "1", pages = "67-73", doi = "https://doi.org/10.1099/00222615-5-1-67", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-5-1-67", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "Summary Since 1-hydroxyphenazine was found to inhibit mitochondrial respiration, attempts were made to determine whether this material would affect whole cells. Oxygen uptake by mouse liver L ā€œSā€ cells, hamster kidney cells (BHK strain C13) and guinea-pig peritoneal macrophages was inhibited by 1-hydroxyphenazine and pyocyanin. In-vivo experiments confirmed that these compounds permeated the cell membrane. Pyocyanin did not inhibit mitochondrial respiration, and the hypothesis was put forward that this compound is acted on by a demethylase to produce the inhibitory 1-hydroxyphenazine and thus cause inhibition of cell respiration.", }