Rifampicin In Experimental Infection Free

Abstract

Summary

The in-vitro sensitivity of 32 strains of to rifampicin was found to be similar to that of . tuberculosis. A 1-mth course of rifampicin in three different dosage regimens was used to treat experimental infection of mouse foot-pads starting 2 and 5 wk after infection. Each regimen led to clinical improvement, but the disease relapsed 6–8 wk after completion of therapy. Treatment of severe lesions for 10 wk produced apparent cure. A 1-mth course of sulphadoxine plus pyrimethamine or of clofazimine proved ineffective, and combination of these with rifampicin were no more effective than rifampicin alone.

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/content/journal/jmm/10.1099/00222615-5-1-39
1972-02-01
2024-03-28
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