%0 Journal Article %A Hopewell, J. W. %A Holt, L. B. %A Desombre, T. R. %T An Electron-Microscope Study Of Intracerebral Infection Of Mice With Low-Virulence Bordetella Pertussis %D 1972 %J Journal of Medical Microbiology, %V 5 %N 1 %P 154-157 %@ 1473-5644 %R https://doi.org/10.1099/00222615-5-1-154 %I Microbiology Society, %X Summary An electron-microscope study of experimentally infected mouse brain after intracerebral challenge with a low-virulence strain of Bordetella pertussis has shown the site of infection to be extracellular and between the microvilli of the ependymal cells. The types of local cells reacting in response to the infection were the ependymal cells and the underlying neuroglia, the latter reaching the ventricular space between the ependymal cells. Evidence of phagocytosis by the two different cell-types was found and there was evidence of subsequent bacterial destruction within these cells. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-5-1-154