1887

Journal of Medical Microbiology logo

Volume 5, Issue 1

Reduction In The Ability Of To React With Antibodies After Long Exposure To Immune Mechanisms Free

Abstract

Summary

Antigenic studies on variants of isolated from infected rabbits at different intervals were carried out by agglutination and by opsonic adherence tests with corresponding antisera isolated from the same rabbits. Organisms isolated from infected rabbits 2 and 5 wk after infection were relatively inagglutinable by sera collected at the same time and 3 wk later from the rabbit from which the trypanosomes were derived.

Experiments on adherence of trypanosomes to macrophages in the presence of antibodies indicated the lack of opsonic adherence particularly in the presence of a prozone. These results suggest possible antigenic loss in the presence of antibodies.

  • Received:
  • Accepted:
  • Published Online:
© J. MED. MICROBIOL. 1972
Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-5-1-131
1972-02-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jmm/5/1/medmicro-5-1-131.html?itemId=/content/journal/jmm/10.1099/00222615-5-1-131&mimeType=html&fmt=ahah

References

  1. Gray A. R. 1962; The influence of antibody on serological variation in Trypanosoma brucei. Ann Trop Med Parasit 56:4
     [Google Scholar]
  2. Gray A. R. 1965; Antigenic variation in clones of Trypanosoma brucei. I. Immunological relationships of the clones. Ann Trop Med Parasit 59:27
     [Google Scholar]
  3. Gray A. R. 1967; Some principles of the immunology of trypanosomiasis. Bull Wld Hlth Org 37:177
     [Google Scholar]
  4. Lumsden W. H. R. 1967; Trends in research on the immunology of trypanosomiasis. Bull Wld Hlth Org 37:167
     [Google Scholar]
  5. Polge C., Soltys M. A. 1957; Preservation of trypanosomes in the frozen state.. Trans Roy Soc Trop Med Hyg 51:519
     [Google Scholar]
  6. Soltys M. A. 1957a; Immunity in trypanosomiasis. I. Neutralization reaction. Parasitology 47:375
     [Google Scholar]
  7. Soltys M. A. 1957b; Immunity in trypanosomiasis. II. Agglutination reaction with African trypanosomes. Parasitology 47:390
     [Google Scholar]
  8. Tizard I. R. 1969; Macrophage cytophilic antibody in mice. Differentiation between antigen adherence due to these antibodies and opsonic adherence. Int Archs Allergy Appl Immun 36:332
     [Google Scholar]
  9. Watkins J. F. 1964; Observations on antigenic variation in a strain of Trypanosoma brucei growing in mice. J Hyg Camb 62:69
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-5-1-131
Loading
Reduction In The Ability Of Trypanosoma Brucei To React With Antibodies After Long Exposure To Immune Mechanisms In Vivo
J. Med. Microbiol. 5, 131 (1972); https://doi.org/10.1099/00222615-5-1-131
/content/journal/jmm/10.1099/00222615-5-1-131
/content/journal/jmm/10.1099/00222615-5-1-131
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error