1887

Abstract

Summary

Rabbit anti-idiotypic antibodies (anti-Id-ab) against lipopolysaccharide (LPS) were obtained with monoclonal immunoglobulins. Their complementary character to the original antigen was confirmed by immunohistochemical analysis and ELISA and gel precipitation tests. The anti-Id-ab were shown to possess all essential properties of Ab2 subtype. Both in-vitro and in-vivo experiments demonstrated a pronounced adjuvant activity of anti-Id-ab without the toxic effect characteristic of LPS. Combined immunisation with anti-Id-ab plus the FI capsular antigen led to a significant increase in the protective immune response against experimental acute challenge with virulent .

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/content/journal/jmm/10.1099/00222615-48-8-751
1999-08-01
2019-08-22
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-48-8-751
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