1887

Abstract

Summary

The relationship between morphological changes and endotoxin release induced by carbapenems in a clinical isolate of was examined. The time-course and magnitude of endotoxin release induced varied among imipenem, panipenem, meropenem and biapenem and related to the morphological changes caused by these agents which variously affected cell shape, cell-wall disintegration and cell lysis. The amount of endotoxin released by carbapenem-treated cells correlated with both the cell-wall morphology and bacterial shape immediately before lysis. Meropenem and biapenem caused markedly increased endotoxin release during cell lysis and cell-wall disintegration, whereas imipenem and panipenem caused much less release of endotoxin.

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/content/journal/jmm/10.1099/00222615-48-3-309
1999-03-01
2019-10-14
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-48-3-309
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