@article{mbs:/content/journal/jmm/10.1099/00222615-48-1-67, author = "KRISTENSEN, B. and SMEDEGAARD, H. H. and PEDERSEN, H. M. and ANDERSEN, M. F. and DAHLERUP, J. F. and SØRENSEN, H. T. and KORSAGER, B. and SCHØNHEYDER, H. C.", title = "Antibiotic resistance patterns among blood culture isolates in a Danish county 1981-1995", journal= "Journal of Medical Microbiology", year = "1999", volume = "48", number = "1", pages = "67-71", doi = "https://doi.org/10.1099/00222615-48-1-67", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-48-1-67", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "All episodes of bacteraemia during a 15-year period (1981-1995) in the County of Northern Jutland, Denmark, were analysed with regard to antibiotic resistance. A total of 8840 isolates from 7938 episodes of bacteraemia was identified. Over time, no changes in bacterial aetiology were noted. Three isolates of Staphylococcus aureus were methicillin resistant (0.2%) and six were gentamicin resistant (0.4%). Among coagulase-negative staphylococci a 14% increase in resistance to penicillin was observed (95% confidence intervals, CI: 2-26%). Likewise, the frequency of resistance to methicillin, gentamicin and erythromycin increased, the corresponding figures being 38% (CI: 26-50%), 26% (CI: 14-38%) and 32% (CI: 16-50%), respectively, whereas a 14% decrease in resistance to streptomycin was recorded (CI: 4-24%). A 20% (CI: 2-37%) increase of coagulase-negative staphylococci resistant to three or more antibiotics was observed. The frequency of ampicillin resistance increased by 9% among Escherichia coli (CI: 4-13%) and by 10% (CI: 6-14%) in all Enterobacteriaceae. Among Enterobacteriaceae the level of resistance to third-generation cephalosporins, carbapenems, aminoglycosides and fluoroquinolones remained low (<1%). The frequency of resistance to three or more antibiotics remained fairly stable among Enterobacteriaceae, although a slight increase was noted among E. coli (5%; CI: 0-10%) The recommended regimen for empirical antibiotic treatment in this region (a combination of penicillin G or ampicillin and an aminoglycoside) provided an overall coverage of 94% (CI: 94-95%), although a slight decrease was noted at the end of the period. In conclusion, acquired antibiotic resistance was maintained at a low level compared with most other European countries and regions during the 15-year period studied.", }