The susceptibilities of 40 strains of various species to 10 classes of antimicrobial agents were compared by a broth microdilution method. the strains tested comprised 20 strains of four AIDS-associated species – (1 strain), (5 strains), (6 strains) and (8 strains) – nine strains of the urogenital tract species and 11 strains of . the results demonstrated wide variation in the susceptibilities of the different spp. to different classes of antimicrobial agent. All the mycoplasmas were susceptible or highly susceptible to the fluoroquinolones, with sparfloxacin the most active, and to the diterpine antibiotic tiamulin. and strains were also highly susceptible to the macrolides, particularly azithromycin and had similar antibiotic susceptibility patterns to most other antimicrobial agents. However, all strains of were resistant to streptomycin (MIC 250–>500 mg/L) whereas all isolates, except the MAC strain, were susceptible (MICs 1.25–12.5 mg/L). isolates varied considerably in their susceptibility to macrolides (MIC range azithromycin 0.0025–>100 mg/L). strains were susceptible to the tetracyclines, lincosamides and mupirocin, but varied in susceptibility to aminoglycosides. Most strains were susceptible to the tetracyclines and all were susceptible to clindamycin and mupirocin. GTU 54 was susceptible to azithromycin, the tetracyclines and lincosamides as well as to the fluoroquinolones and tiamulin.


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