%0 Journal Article %A Mathews, H. L. %A Witek-Janusek, Linda %T Antifungal activity of interleukin-2-activated natural killer (NK1.1+) lymphocytes against Candida albicans %D 1998 %J Journal of Medical Microbiology, %V 47 %N 11 %P 1007-1014 %@ 1473-5644 %R https://doi.org/10.1099/00222615-47-11-1007 %I Microbiology Society, %X Summary Interleukin-2 (IL-2)-activated lymphocytes interact directly with, and inhibit, the growth of Candida albicans hyphae. C. albicans-stimulated natural killer (NK1.1+) lymphocytes were demonstrated to secrete a soluble product capable of directly affecting C. albicans yeast forms. Antibodies specific for interferon-γ completely eliminated the antifungal activity of the NK1.1+ lymphocyte product and diminished the antifungal activity of NK1.1+ lymphocytes against C. albicans. Antibodies specific for other cytokines had no such effect. These data demonstrate that C. albicans-stimulated NK1.1+ lymphocytes have antifungal activity against C. albicans yeast cells via the release of interferon-γ. This antifungal activity was demonstrable only against the yeast form of the fungus, with no effect on C. albicans hyphae. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-47-11-1007