The T-agglutination types were determined for a diverse collection of 1531 group A streptococci for which the 5′ M protein gene () sequences had been analysed. The majority of the T-agglutination types correlated with previously seen M//T-type associations; however, several new associations were found. Analysis of a subset of this collection - which included 1157 clinical isolates with multiply encountered types - found that amplicon restriction profiles of isolates sharing identical T types and opacity factor phenotypes are useful for detecting groups of isolates with identical genes. Many genes of known 5′ sequence display a highly conserved restriction pattern amongst clinical isolates widely separated both geographically and temporally.


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