1887

Abstract

A total of 5348 isolates of was serotyped and screened for insusceptibility to tetracycline, penicillin, erythromycin and chloramphenicol. Of these, 4238 (79%) were isolated from patients who had pneumonia or meningitis or were bacteraemic. Altogether, 3948 (74%) of the isolates belonged to one or other of the serotypes 1, 3, 4, 6, 8, 9, 14, 19 or 23 with serotypes 6, 14, 18, 19 and 23 being frequent causes of invasive disease in young children. Many isolates of type 1 were isolated from pneumonia and few from meningitis. Some 768 (14%) isolates were insusceptible to one or more antibiotic and 591 of these belonged to serotypes 6, 9, 14, 19 or 23. Representatives of type 14 resistant to erythromycin were prominent from 1986 onwards. There was an increase in the number of multi-resistant pneumococci from 1985. Among these were isolates of type 23 insusceptible to penicillin, chloramphenicol and tetracycline and cultures of type 6 resistant additionally to erythromycin.

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1998-01-01
2024-04-25
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References

  1. Henrichsen J. Six newly recognized types of Streptococcus pneumoniae. J Clin Microbiol 1995; 33:2759–2762
    [Google Scholar]
  2. Venkateswaran P. S., Stanton N., Austrian R. Type variation of strains of Streptococcus pneumoniae in capsular serogroup 15. J Infect Dis 1983; 147:1041–1054
    [Google Scholar]
  3. Hodges R. G., MacLeod C. M. Epidemic pneumococcal pneumonia. I. Description of the epidemic. Am J Hyg 1946; 44:183–192
    [Google Scholar]
  4. Aszkenasy O. N., George R. C., Begg N. T. Pneumococcal bacteraemia and meningitis in England and Wales 1982 to 1992. Commun Dis Rep CDR Rev 1995; 5:R45–R50
    [Google Scholar]
  5. Lund E. Types of pneumococci found in blood, spinal fluid and pleural exudate during a period of 15 years (1954-1969). Acta Path Microbiol Scand B Microbiol Immunol 1970; 78:333–336
    [Google Scholar]
  6. Nielsen S. V., Henrichsen J. Capsular types and susceptibility to penicillin of pneumococci isolated from cerebrospinal fluid or blood in Denmark, 1983-1988. Scand J Infect Dis 1993; 25:165–170
    [Google Scholar]
  7. Klugman K. P., Koomhof H. J. Drug resistance patterns and serogroups or serotypes of pneumococcal isolates from cerebrospinal fluid or blood, 1979-1986. J Infect Dis 1988; 158:956–964
    [Google Scholar]
  8. Greenwood B. M., Hassan-King M., MacFarlane J. T. Pneumococcal serotypes in West Africa. Lancet 1980; 1:360
    [Google Scholar]
  9. Austrian R. Untreated pneumococcal bacteraemia of cryptic origin in the human adult with spontaneous recovery. S Afr Med J 1986 October 11; Supplement S46–S49
    [Google Scholar]
  10. Riley I. D., Douglas R. M. An epidemiologic approach to pneumococcal disease. Rev Infect Dis 1981; 3:233–245
    [Google Scholar]
  11. Hansman D. Serotypes in pneumococcal disease. A ten year study in Australia 1970 through 1979. Aust NZ J Med 1983; 13:359–364
    [Google Scholar]
  12. Orange M., Gray B. M. Pneumococcal serotypes causing disease in children in Alabama. Pediatr Infect Dis J 1993; 12:244–246
    [Google Scholar]
  13. Klugman K. P. Pneumococcal resistance to antibiotics. Clin Microbiol Rev 1990; 3:171–196
    [Google Scholar]
  14. Abraham E. P., Chain E., Fletcher C. M. Further observations on penicillin. Lancet 1941; 2:177–189
    [Google Scholar]
  15. Watson D. A., Musher D. M., Jacobson J. W., Verhoef J. A brief history of the pneumococcus in biomedical research: a panoply of scientific discovery. Clin Infect Dis 1993; 17:913–924
    [Google Scholar]
  16. Evans W., Hansman D. Tetracycline-resistant pneumococcus. Lancet 1963; 1:451
    [Google Scholar]
  17. Hansman D., Bullen M. M. A resistant pneumococcus. Lancet 1967; 2:264–265
    [Google Scholar]
  18. Dixon J. M. S. Pneumococcus resistant to erythromycin and lincomycin. Lancet 1967; 1:573
    [Google Scholar]
  19. Cybulska J., Jeljaszewicz J., Lund E., Munksgaard A. Prevalence of types of Diplococcus pneumoniae and their susceptibility to 30 antibiotics. Chemotherapy 1970; 15:304–316
    [Google Scholar]
  20. Jacobs M. R., Koomhof H. J., Robins-Browne R. M. Emergence of multiply resistant pneumococci. N Engl J Med 1978; 299:735–740
    [Google Scholar]
  21. Colman G., Hallas G. Systemic disease caused by pneumococci. J Infect 1983; 7:248–255
    [Google Scholar]
  22. Johnson A. P., Speller D. C. E., George R. C., Warner M., Domingue G., Efstratiou A. Prevalence of antibiotic resistance and serotypes in pneumococci in England and Wales: results of observational surveys in 1990 and 1995. BMJ 1996; 312:1454–1456
    [Google Scholar]
  23. Lund E. Diagnosis of pneumococci by the optochin and bile tests. Acta Path Microbiol Scand 1959; 47:308–315
    [Google Scholar]
  24. Colman G. The classification of streptococcal strains. PhD thesis University of London; 1970312
    [Google Scholar]
  25. Austrian R., Buettger C., Dole M. Problems in the classification and pathogenic role of alpha and nonhemolytic streptococci of the human respiratory tract. In Wannamaker L. W., Matsen J. M. (eds) Streptococci and streptococcal diseases: recognition, understanding, and management New York: Academic Press; 1972355–370
    [Google Scholar]
  26. Kauffmann F., Lund E., Eddy B. E. Proposal for a change in the nomenclature of Diplococcus pneumoniae and a comparison of the Danish and American type designations. Int Bull Bacteriol Nomen Taxon 1960; 10:31–40
    [Google Scholar]
  27. Smart L. E. Serotyping of Streptococcus pneumoniae strains by coagglutination. J Clin Pathol 1986; 39:328–331
    [Google Scholar]
  28. Lund E., Henrichsen J. Laboratory diagnosis, serology and epidemiology of Streptococcus pneumoniae. In Bergan T., Norris J. R. (eds) Methods in microbiology Vol 12 London: Academic Press; 1978241–262
    [Google Scholar]
  29. Snell J. J. S., George R. C., Perry S. F., Erdman Y. J. Antimicrobial susceptibility testing of Streptococcus pneumoniae’, quality assessment results. J Clin Pathol 1988; 41:384–387
    [Google Scholar]
  30. Dixon J. M. S., Lipinski A. E., Graham M. E. P. Detection and prevalence of pneumococci with increased resistance to penicillin. Can Med Assoc J 1977; 117:1159–1161
    [Google Scholar]
  31. Hansman D., Morris S. Pneumococcal carriage amongst children in Adelaide, South Australia. Epidemiol Infect 1988; 101:411–417
    [Google Scholar]
  32. Scott J. A. G., Hall A. J., Dagan R. Serogroup-specific epidemiology of Streptococcus pneumoniae: assocations with age, sex, and geography in 7, 000 episodes of invasive disease. Clin Infect Dis 1996; 22:973–981
    [Google Scholar]
  33. Taunay A. E., Austrian R., Landgraf I. M., Vieira M. F. P., Melles C. E. A. Sorotipos de Streptococcus pneumoniae isolados de liquido cefalorraquidiano no periodo de 1977-1988 na cidade de São Paulo, Brasil. [Serotypes of Streptococcus pneumoniae isolated from cerebrospinal fluid in 1977–1988 in Sao Paulo City, Brazil]. Rev Inst Med Trop São Paulo 1990; 32:11–15
    [Google Scholar]
  34. Gratten M., Morey F., Dixon J. An outbreak of serotype 1 Streptococcus pneumoniae infection in central Australia. Med J Aust 1993; 158:340–342
    [Google Scholar]
  35. Janoff E. N., Breiman R. F., Daley C. L., Hopewell P. C. Pneumococcal disease during HIV infection. Epidemiologic, clinical, and immunologic perspectives. Ann Int Med 1992; 117:314–324
    [Google Scholar]
  36. Bratton L., Teele D. W., Klein J. O. Outcome of unsuspected pneumococcemia in children not initially admitted to hospital. J Pediatr 1977; 90:703–706
    [Google Scholar]
  37. Gruer L. D., McKendrick M. W., Geddes A. M. Pneumonococcal bacteraemia-a continuing challenge. Q J Med 1984; 53:259–270
    [Google Scholar]
  38. Walker W. Splenectomy in childhood: a review in England and Wales, 1960-4. Br J Surg 1976; 63:36–43
    [Google Scholar]
  39. Gaston M. H., Verter J. I., Woods G. Prophylaxis with oral pencillin in children with sickle cell anemia. A randomized trial. N Engl J Med 1986; 314:1593–1599
    [Google Scholar]
  40. Turk D. C. Frequencies of pneumonoccal types causing serious infections in patients admitted to the Radcliffe Infirmary, Oxford, 1969-77. J Hyg 1978; 81:227–238
    [Google Scholar]
  41. Lund E. Distribution of age and sex in cases of pneumococcal meningitis. Acta Path Microbiol Scand 1964; 61:487–490
    [Google Scholar]
  42. Smit P., Oberholzer D., Hayden-Smith S., Koomhof H. J., Hilleman M. R. Protective efficacy of pneumococcal polysaccharide vaccines. JAMA 1977; 238:2613–2616
    [Google Scholar]
  43. Butler J. C., Breiman R. F., Campbell J. F., Lipman H. B., Broome C. V., Facklam R. R. Pneumococcal polysaccharide vaccine efficacy. An evaluation of current recommendations. JAMA 1993; 270:1826–1831
    [Google Scholar]
  44. John A. B., Ramlal A., Jackson H., Maude G. H., Waight Sharma A., Seijeant G. R. Prevention of pneumococcal infection in children with homozygous sickle cell disease. BMJ 1984; 288:1567–1570
    [Google Scholar]
  45. Nelson J. D., Scheetz M. D. (eds) Proceedings of a workshop on vaccines for otitis media. Pediatr Infect Dis J 1989; 8: Suppl S1–S97
    [Google Scholar]
  46. Jacobs N. M. Pneumococcal osteomyelitis and arthritis in children. A hospital series and literature review. Am J Dis Child 1991; 145:70–74
    [Google Scholar]
  47. Denis F., Mounier M., Descottes B., Cubertafond P., Catanzano G. Abdominal infections caused by Streptococcus pneumoniae. Eur J Clin Microbiol 1984; 3:443
    [Google Scholar]
  48. McFarlane A. C., Hamra L. K., Reiss-Levy E., Hansman D. Pneumococcal peritonitis in adolescent girls. Med J Aust 1979; 1:100–101
    [Google Scholar]
  49. Gruer L. D., Collingham K. E., Edwards C. W. Pneumonococcal peritonitis associated with an IUCD. Lancet 1983; 2:677
    [Google Scholar]
  50. McCartney J. E. The pathogenesis of primary pneumococcal peritonitis. J Pathol Bacteriol 1923; 26:507–517
    [Google Scholar]
  51. Austrian R., Gold J. Pneumococcal bacteremia with especial reference to bacteremic pneumococcal pneumonia. Ann Int Med 1964; 60:759–776
    [Google Scholar]
  52. Bergqvist G., Trovik M. Neonatal infections with Streptococcus pneumoniae. Scand J Infect Dis 1985; 17:33–35
    [Google Scholar]
  53. Primhak R. A., Tanner M. S., Spencer R. C. Pneumococcal infection in the newborn. Arch Dis Child 1993; 69:317–318
    [Google Scholar]
  54. Shayegani M., Parsons L. M., Gibbons W. E., Campbell D. Characterization of nontypable Streptococcus pneumoniaeAsks organisms isolated from outbreaks of conjunctivitis. J Clin Micrbiol 1982; 16:8–14
    [Google Scholar]
  55. Finland M., Barnes M. W. Changes in occurrence of capsular serotypes of Streptococcus pneumoniae at Boston City Hospital during selected years between 1935 and 1974. J Clin Microbiol 1977; 5:154–166
    [Google Scholar]
  56. Smart L. E., Dougall A. J., Girdwood R. W. A. New 23-valent pneumococcal vaccine in relation to pneumococcal serotypes in systemic and non-systemic disease. J Infect 1987; 14:209–215
    [Google Scholar]
  57. Bridges-Webb C., Dunstone M. W. The Australian general practice morbidity and prescribing survey 1969 to 1974: respiratory infections. Med J Aust 1976; 2: Special Suppl 118–20
    [Google Scholar]
  58. Smart L. E., Platt D. J., Timbury M. C. A comparison of the distribution of pneumococcal types in systemic disease and the upper respiratory tract in adults and children. Epidemiol Infect 1987; 98:203–209
    [Google Scholar]
  59. Ward J., Koomhof H. Antibiotic-resistant pneumococci. In Remington J. S., Swartz M. N. (eds) Current clinical topics in infectious diseases Vol 1 New York: McGraw-Hill Book Company; 1980265–287
    [Google Scholar]
  60. Kontiainen S., Sivonen A. Optochin resistance in Streptococcus pneumoniae strains isolated from blood and middle ear fluid. Eur J Clin Microbiol 1987; 6:422–424
    [Google Scholar]
  61. Turner G. C. Tetracycline-resistant pneumococci in a general hospital. Lancet 1963; 2:1292–1295
    [Google Scholar]
  62. Percival A., Armstrong E. C., Turner G. C. Increased incidence of tetracycline-resistant pneumococci in Liverpool in 1968. Lancet 1969; 1:998–1000
    [Google Scholar]
  63. Kensit J., Farrell W., Evans S. Tetracycline resistance in pneumococci and group A streptococci. Report of an ad-hoc study group on antibiotic resistance. BMJ 1977; 1:131–133
    [Google Scholar]
  64. Howard A. J., Hince C. J., Williams J. D. Antibiotic resistance in Streptococcus pneumoniae and Haemophilus influenzae. Report of a study group on bacterial resistance. BMJ 1978; 1:1657–1660
    [Google Scholar]
  65. Verhaegen J., Goubau P., Verbist L., Glupczynski J., Blogie M., Yourassowsky E. Erythromycin-resistant Streptococcus pneumoniae. Lancet 1988; 2:1432–1433
    [Google Scholar]
  66. Young F. E., Mayer L. Genetic determinants of microbiol resistance to antibiotics. Rev Infect Dis 1979; 1:55–63
    [Google Scholar]
  67. George R. C., Ball L. C., Cooper P. G. Antibiotic-resistant pneumococci in the United Kingdom. Commun Dis Rep CDR Rev 1992; 2:R37–R43
    [Google Scholar]
  68. Dowson C. G., Johnson A. P., Cercenado E., George R. C. Genetics of oxacillin resistance in clinical isolates of Streptococcus pneumoniae that are oxacillin resistant and penicillin susceptible. Antimicrob Agents Chemother 1994; 38:49–53
    [Google Scholar]
  69. Dowson C. G., Hutchison A., Brannigan J. A. Horizontal transfer of penicillin-binding protein genes in pencillin-resistant clinical isolates of Streptococcus pneumoniae. Proc Natl Acad Sci USA 1989; 86:8842–8846
    [Google Scholar]
  70. Pallett A. P., Strangeways J. E. M. Penicillin-resistant pneumococci. Lancet 1988; 1:1452
    [Google Scholar]
  71. Boulnois G. J. Pneumococcal proteins and the pathogenesis of disease caused by Streptococcus pneumoniae. J Gen Microbiol 1992; 138:249–259
    [Google Scholar]
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