1887

Abstract

To analyse the immune response of mice to infection, BALB/c mice were inoculated intraperitoneally with strain 406K, and the titres of -specific immunoglobulins - IgM, IgG1, IgG2a, IgG2b and IgG3 - were determined by ELISA. IgM antibodies appeared first, followed by IgG2a and IgG3, and then IgG1 and IgG2b. The protective activity of individual classes and subclasses of -specific immunoglobulins was then determined by passive immunisation of BALB/c mice with immunoglobulin preparations purified by affinity chromatography. The mice were then challenged by intraperitoneal inoculation of The study demonstrated that -specific IgM and IgG3 protected against the development of spirochaetaemia and death after borrelial infection, whereas -specific IgG1, IgG2a and IgG2b had low protective activities.

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/content/journal/jmm/10.1099/00222615-46-8-675
1997-08-01
2019-11-21
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-46-8-675
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