1887

Abstract

is an asexual diploid fungus that can express high frequency phenotypic switching. Switched variants can develop structured aerial mycelia (SAM) and cultures that have been grown for a protracted period exhibit satellite colonies. This study investigated the development of both SAM and satellite colonies by means of a freeze-drying technique and scanning electron microscopy. The results show that SAM may develop due to hyphae developing in the colony at the base of the structures. The development of satellite colonies is a result of cells that have grown deep into the agar re-emerging on to the agar/air surface and producing a new colony. Although both SAM and satellite colonies are often seen together on mature colonies, their cause and development are different.

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/content/journal/jmm/10.1099/00222615-46-4-326
1997-04-01
2022-09-30
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References

  1. Slutsky B., Buffo J., Soli D. R. High-frequency switching of colony morphology in Candida albicans . Science 1985; 230:666–669
    [Google Scholar]
  2. Di Menna M. E. Natural occurrence of rough variant of a yeast, Candida albicans . Nature 1952; 169:550–551
    [Google Scholar]
  3. Mackinnon J. E. Dissociation in Candida albicans . J Infect Dis 1940; 66:59–77
    [Google Scholar]
  4. Brown-Thomsen J. Variability in Candida albicans. (Robin) Berkhout. 1. Studies on morphology and biochemical activity. Hereditas 1968; 60:355–398
    [Google Scholar]
  5. Iralu V. Formation of aerial hyphae in Candida albicans . Appl Microbiol 1971; 22:482–488
    [Google Scholar]
  6. Pomes R., Gil C., Nombela C. Genetic analysis of Candida albicans morphological mutants. J Gen Microbiol 1985; 131:2107–2113
    [Google Scholar]
  7. Anderson J. M., Soil D. R. Unique phenotype of opaque cells in the white-opaque transition of Candida albicans . J Bacteriol 1987; 169:5579–5588
    [Google Scholar]
  8. Lee K. L., Buckley H. R., Campbell C. C. An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida albicans . Sabouraudia 1975; 13:148–153
    [Google Scholar]
  9. Soil D. R., Morrow B., Srikantha T., Vargas W., Wertz P. Developmental and molecular biology of switching in Candida albicans . Oral Surg Oral Med Oral Pathol 1994; 78:194–201
    [Google Scholar]
  10. Suzuki T., Kobayashi I., Kanbe T., Tanaka K. High frequency variation of colony morphology and chromosome reorganization in the pathogenic yeast Candida albicans . J Gen Microbiol 1989; 135:425–434
    [Google Scholar]
  11. Rustchenko-Bulgac E. P., Sherman F., Hicks J. B. Chromosomal rearrangements associated with morphological mutants provide a means for genetic variation of Candida albicans . J Bacteriol 1990; 172:1276–1283
    [Google Scholar]
  12. Joshi K. R., Gavin J. B. The morphology of colony variants of three species of Candida . Sabouraudia 1975; 13:274–279
    [Google Scholar]
  13. Whittaker D. K., Drucker D. B. Scanning electron microscopy of intact colonies of microorganisms. J Bacteriol 1970; 104:902–909
    [Google Scholar]
  14. Radford D. R., Challacombe S. J., Walter J. D. A scanning electronmicroscopy investigation of the structure of colonies of different morphologies produced by phenotypic switching of Candida albicans . J Med Microbiol 1994; 40:416–423
    [Google Scholar]
  15. Salfelder K., Ueda K., Quiroga E. L., Schwarz J. Visceral candidosis. Anatomic study of 34 cases. Curr Top Pathol 1977; 64:177–224
    [Google Scholar]
  16. Soli D. R. High-frequency switching in Candida albicans . Clin Microbiol Rev 1992; 5:183–203
    [Google Scholar]
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