1887

Abstract

A strain of (H37Rv) considered virulent for mice and a strain (R1Rv) considered relatively avirulent were compared for their ability to survive host immunity in the lungs and to induce lung pathology. Although both strains of were capable of causing a slowly progressive infection in the lungs of immunocompetent mice, only the H37Rv strain was capable of inducing progressive destructive pathology and of causing loss of lung function over a 300-day period. Therefore, the ability to survive host immunity in the lungs and the ability to cause lung pathology are separate manifestations of mycobacterial virulence.

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1996-08-01
2022-01-24
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