The naturally occurring plasmid pSTS7 from mediated resistance to tetracycline L gene and to kanamycin and neomycin an D gene. Plasmid pSTS7 showed partial restriction map and sequence homology to the previously described tetracycline resistance plasmid pNS1981 from and to the kanamycin/neomycin/bleomycin resistance plasmid pUB110 from . Sequence analysis of the regions flanking the two resistance genes in pSTS7 led to the identification of a novel site for interplasmid recombination which could explain the derivation of pSTS7 from the incompatible pNS1981- and pUB110-like parental plasmids under tetracycline-selective pressure.


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