1887

Abstract

The naturally occurring plasmid pSTS7 from mediated resistance to tetracycline L gene and to kanamycin and neomycin an D gene. Plasmid pSTS7 showed partial restriction map and sequence homology to the previously described tetracycline resistance plasmid pNS1981 from and to the kanamycin/neomycin/bleomycin resistance plasmid pUB110 from . Sequence analysis of the regions flanking the two resistance genes in pSTS7 led to the identification of a novel site for interplasmid recombination which could explain the derivation of pSTS7 from the incompatible pNS1981- and pUB110-like parental plasmids under tetracycline-selective pressure.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-45-1-57
1996-07-01
2024-05-26
Loading full text...

Full text loading...

/deliver/fulltext/jmm/45/1/medmicro-45-1-57.html?itemId=/content/journal/jmm/10.1099/00222615-45-1-57&mimeType=html&fmt=ahah

References

  1. Levy S. B. Resistance to the tetracyclines. In Bryan L. E. (ed) Antimicrobial drug resistance Orlando: Academic Press; 1984191–240
    [Google Scholar]
  2. Chopra I., Hawkey P. M., Hinton M. Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother 1992; 29:245–277
    [Google Scholar]
  3. Cooksey R. C., Baldwin J. N. Relatedness of tetracycline resistance plasmids among species of coagulase-negative staphylococci. Antimicrob Agents Chemother 1985; 27:234–238
    [Google Scholar]
  4. Schwarz S., Cardoso M., Grölz-Krug S., Blobel H. Common antibiotic resistance plasmids in Staphylococcus aureus and Staphylococcus epidermidis from human and canine infections. Zentralbl Bakteriol 1990; 273:369–377
    [Google Scholar]
  5. Lyon B. R., Skurray R. Antimicrobial resistance of Staphylococcus aureus: genetic basis. Microbiol Rev 1987; 51:88–134
    [Google Scholar]
  6. Schwarz S., Noble W. C. Tetracycline resistance genes in staphylococci from the skin of pigs. J Appl Bacteriol 1994; 76:320–326
    [Google Scholar]
  7. Khan S. A., Novick R. P. Complete nucleotide sequence of pT181, a tetracycline-resistance plasmid from Staphylococcus aureus. Plasmid 1983; 10:251–259
    [Google Scholar]
  8. Mojumdar M., Khan S. A. Characterization of the tetracycline resistance gene of plasmid pT181 of Staphylococcus aureus. J Bacteriol 1988; 170:5522–5528
    [Google Scholar]
  9. Guay G. G., Khan S. A., Rothstein D. M. The tet(K) gene of plasmid pT181 of Staphylococcus aureus encodes an efflux protein that contains 14 transmembrane helices. Plasmid 1993; 30:163–166
    [Google Scholar]
  10. Levy S. B. Tetracycline resistance determinants are widespread. ASM News 1988; 54:418–421
    [Google Scholar]
  11. Schwarz S., Cardoso M., Wegener H. C. Nucleotide sequence and phylogeny of the tet(L) tetracycline resistance determinant encoded by the plasmid pSTE1 from Staphylococcus hyicus. Antimicrob Agents Chemother 1992; 36:580–588
    [Google Scholar]
  12. Hoshino T., Ikeda T., Tomizuka N., Furukawa K. Nucleotide sequence of the tetracycline resistance gene of pTHT15, a thermophilic Bacillus plasmid: comparison with staphylococcal TCR controls. Gene 1985; 37:131–138
    [Google Scholar]
  13. Shishido K., Tanaka Y. A restriction map of Bacillus subtilis tetracycline-resistance plasmid pNS1981. Plasmid 1984; 12:65–66
    [Google Scholar]
  14. Sakaguchi R., Shishido K., Hoshino T., Furukawa K. The nucleotide sequence of the tetracycline resistance gene of plasmid pNS 1981 from Bacillus subtilis differs from pTHT 15 from a thermophilic Bacillus by two base pairs. Plasmid 1986; 16:72–73
    [Google Scholar]
  15. Palva A., Vidgren G., Simonen M., Rintala, H, Laamanen P. Nucleotide sequence of the tetracycline resistance gene of pBC16 from Bacillus cereus. Nucleic Acids Res 1990; 18:1635
    [Google Scholar]
  16. McKenzie T., Hoshino T., Tanaka T., Sueoka N. The nucleotide sequence of PUB110: some salient features in relation to replication and its regulation. Plasmid 1986; 15:93–103
    [Google Scholar]
  17. McKenzie T., Hoshino T., Tanaka T., Sueoka N. A revision of the nucleotide sequence and functional map of pUB110. Plasmid 1987; 17:83–85
    [Google Scholar]
  18. Sakaguchi R., Shishido K. A unique DNA structure of the junction of homologous and non-homologous regions between tetracycline-resistance plasmid pNS1981 and kanamycin-resistance plasmid pUB110. Nucleic Acids Res 1987; 15:7202
    [Google Scholar]
  19. Barry A., Thomsberry C. Susceptibility tests: diffusion test procedures. In Lennette E. H., Balows A., Hausler W. H., Shadomy H. J. (eds) Manual of clinical microbiology 4th edn Washington DC: American Society for Microbiology; 1985978–987
    [Google Scholar]
  20. Sambrook J., Fritsch E. F., Maniatis T. Molecular cloning: a laboratory manual. 2nd edn Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1989
    [Google Scholar]
  21. Schwarz S., Cardoso M., Blobel H. Plasmid-mediated chloramphenicol resistance in Staphylococcus hyicus. J Gen Microbiol 1989; 135:3329–3336
    [Google Scholar]
  22. Chang S., Cohen S. N. High frequency transformation of Bacillus subtilis protoplasts by plasmid DNA. Mol Gen Genet 1979; 168:111–115
    [Google Scholar]
  23. Dagert M., Ehrlich S. D. Prolonged incubation in calcium chloride improves the competence of Escherichia coli cells. Gene 1979; 6:23–28
    [Google Scholar]
  24. Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 1977; 74:5463–5467
    [Google Scholar]
  25. Polak J., Novick R. P. Closely related plasmids from Staphylococcus aureus and soil bacilli. Plasmid 1982; 7:152–162
    [Google Scholar]
  26. Stewart P. R., Dubin D. T., Chikramane S. G., Inglis B., Matthews P. R., Poston S. M. IS257 and small plasmid insertions in the mec region of the chromosome of Staphylococcus aureus. Plasmid 1994; 31:12–20
    [Google Scholar]
  27. Sakaguchi R., Amano H., Shishido K. Nucleotide sequence homology of the tetracycline-resistance determinant naturally maintained in Bacillus subtilis Marburg 168 chromosome and the tetracycline-resistance gene of B. subtilis plasmid pNS1981. Biochim Biophys Acta 1988; 950:441–444
    [Google Scholar]
  28. Novick R. P. Staphylococcal plasmids and their replication. Annu Rev Microbiol 1989; 43:537–565
    [Google Scholar]
  29. Gennaro M. L., Kornblum J., Novick R. P. A site-specific recombination function in Staphylococcus aureus plasmids. J Bacteriol 1987; 169:2601–2610
    [Google Scholar]
  30. Novick R. P., Projan S. J., Rosenblum W., Edelman I. Staphylococcal plasmid cointegrates are formed by host- and phage-mediated general rec systems that act on short regions of homology. Mol Gen Genet 1984; 195:374–377
    [Google Scholar]
  31. Schwarz S., Noble W. C. Structure and putative origin of a plasmid from Staphylococcus hyicus that mediates chloramphenicol and streptomycin resistance. Lett Appl Microbiol 1994; 18:281–284
    [Google Scholar]
  32. Novick R. P. Plasmid incompatibility. Microbiol Rev 1987; 51:381–395
    [Google Scholar]
  33. Miller R. V., Levy S. B. Horizontal gene transfer in relation to environmental release of genetically engineered microorganisms. In Levy S. B., Miller R. V. (eds) Gene transfer in the environment New York: McGraw-Hill; 1989405–420
    [Google Scholar]
  34. Gruss A., Ehrlich S. D. The family of highly interrelated singlestranded deoxyribonucleic acid plasmids. Microbiol Rev 1989; 53:231–241
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-45-1-57
Loading
/content/journal/jmm/10.1099/00222615-45-1-57
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error