1887

Abstract

IgA and IgG antibodies to cytoplasmic and secreted antigens of serotypes 4 and 8 of and the percentage of agalactosyl immunoglobulin (%Gal[0]) were measured by ELISA in groups of blood donors, HIV seronegative persons, HIV seropositive persons with CD4 cell counts >300/mm and AIDS patients co-infected with No differences were found between the control groups, but HIV seropositive persons were distinguished by their increased %Gal[0] (p < 0.001) and increased IgA titre (p < 0.05) to secreted antigens of both serotypes of Patients going on to develop aviumosis differed from other HIV-positive individuals, having more IgA to secreted antigens of serotype 8 (p < 0.03) and more IgG to secreted antigens of both serotypes (p < 0.001). After developing infection there was a further increase in %Gal[0] (p < 0.0001), IgA titres fell to both types of antigen from serotype 4 (p < 0.01) and sonicate antigen of serotype 8 (p < 0.001) and IgG fell to the secreted antigens of serotype 4 (p < 0.03). One interpretation of these observations is that antibody profiles to might be used to identify healthy persons at special risk of developing HIV seropositivity, and to identify persons with early AIDS who are likely to develop aviumosis.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-44-3-165
1996-03-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jmm/44/3/medmicro-44-3-165.html?itemId=/content/journal/jmm/10.1099/00222615-44-3-165&mimeType=html&fmt=ahah

References

  1. Horsburgh C. R., Selik R. M. The epidemiology of disseminated nontuberculous mycobacterial infection in the Acquired Immunodeficiency Syndrome (AIDS). Am Rev Respir Dis 1989; 139:4–7
    [Google Scholar]
  2. Nightingale S. D., Cameron D. W., Gordin F. M. Two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex infection in AIDS. N Engl J Med 1993; 329:828–833
    [Google Scholar]
  3. Yakrus M. A., Good R. C. Geographic distribution, frequency and specimen source of Mycobacterium avium complex serotypes isolated from patients with acquired immunodeficiency syndrome. J Clin Microbiol 1990; 28:926–929
    [Google Scholar]
  4. Grange J. M., Yates M. D., Boughton E. The avian tubercle bacillus and its relatives. J Appl Bacteriol 1990; 68:411–431
    [Google Scholar]
  5. Horsburgh C. R., Chin D. P., Yajko D. M. Environmental risk factors for acquisition of Mycobacterium avium complex in persons with human immunodeficiency virus infection. J Infect Dis 1994; 170:362–367
    [Google Scholar]
  6. von Reyn C. F., Maslow J. N., Barber T. W., Falkinham J. O., Arbeit R. D. Persistent colonisation of potable water as a source of Mycobacterium avium infection in AIDS. Lancet 1994; 343:1137–1141
    [Google Scholar]
  7. Hoffner S. E., Kallenius G., Petrini B., Brennan P. J., Tsang A. Y. Serovars of Mycobacterium avium complex isolated from patients in Sweden. J Clin Microbiol 1990; 28:1105–1107
    [Google Scholar]
  8. McIntyre G., Stanford J. L. The relationship between immunodiffusion and agglutination serotypes of Mycobacterium avium and Mycobacterium intracellulare . Eur J Respir Dis 1986; 69:135–141
    [Google Scholar]
  9. Khoo S. H., Wilkins E. G. L., Fraser I., Stanford J. L. Lack of T cell response to common mycobacterial antigens in HIV-infected individuals — consequence or a co-factor?. IX International Conference on AIDS, Berlin, June 1993 Abstract no. PO-A 24–0551
    [Google Scholar]
  10. Warburg B. L., Christian T. A method of protein estimation. Biochemische Zeitschrift 1941; 310:384–386
    [Google Scholar]
  11. van Zeben D., Rook G. A. W., Hazes J. M. W. Early agalactosylation of IgG is associated with a more progressive disease course in patients with rheumatoid arthritis: results of a follow-up study. Br J Rheumatol 1994; 33:36–43
    [Google Scholar]
  12. Parekh R., Roitt I., Isenberg D., Dwek R., Rademacher T. Age-related galactosylation of the N-linked oligosaccharides of human serum IgG. J Exp Med 1988; 167:1731–1736
    [Google Scholar]
  13. Clerici M., Shearer G. M. ATH1 to TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993; 14:107–110
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-44-3-165
Loading
/content/journal/jmm/10.1099/00222615-44-3-165
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error