1887

Abstract

Summary

Rotaviruses are the most important cause of severe gastro-enteritis in infants and young children. However, the determinants of protective immunity are poorly understood. Human immunity to rotavirus can be acquired passively or actively. It may be humoral or cell-mediated, protective or non-protective, homotypic or heterotypic and mucosal or systemic, or any combination of these. Mucosal immunity is protective against rotavirus illness, but not against infection, whereas systemic immunity reflects exposure, but probably has little if any role in protection. Both local and cell-mediated immunity are likely to be important in protection. However, there is no agreement as to a reliable surrogate marker of small intestinal protective immunity, and little is known about small intestinal cell-mediated immunity in man, especially infants. Passive mucosal immunity, but not systemic immunity, may contribute to protection in breast-fed infants, and in those at increased risk of serious illness who have been given oral immunoglobulin, either as prophylaxis or therapeutically. Animal and adult studies may have only limited relevance to those who are at greatest risk of serious illness. However, it is probably from such studies that hypotheses about small intestinal cell-mediated immunity in the protection of infants against rotavirus infection and illness will come. The determinants of susceptibility to serious rotavirus infection in man remain unclear, and this continues to hinder vaccine research.

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1995-12-01
2022-09-27
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References

  1. Herrmann J. E., Blacklow N. R. Rotavirus. In Mandell G. L., Douglas R. G., Bennett J. E. (eds) Principles and practice of infectious diseases 3rd edn New York: Churchill Livingstone; 19901234–1240
    [Google Scholar]
  2. Kapikian A. Z., Chanock R. M. Rotaviruses. In Fields B. N., Knipe D. M. (eds) Virology 2nd edn, vol 2 New York Raven Press; 19901353–1404
    [Google Scholar]
  3. Bishop R. F., Barnes G. L., Cipriani E., Lund J. S. Clinical immunityafter neonatal rotavirus infection. A prospective longitudinal study in young children. N Engl J Med 1983; 309:72–76
    [Google Scholar]
  4. Estes M. K. Rotaviruses and their replication. In Fields B. N., Knipe D. M. (eds) Virology 2nd edn, vol 2 New York: Raven Press; 19901329–1352
    [Google Scholar]
  5. Desselberger U. Towards rotavirus vaccines. Rev Med Virol 1993; 3:15–21
    [Google Scholar]
  6. Hoshino H., Kapikian A. Z. Rotavirus vaccine development forthe prevention of severe diarrhea in infants and young children. Trends Microbiol 1994; 2:242–249
    [Google Scholar]
  7. Bernstein D. I., Sander D. S., Smith V. E., Schiff G. M., Ward R. L. Protection from rotavirus reinfection: 2-year prospective study. J Infect Dis 1991; 164:277–283
    [Google Scholar]
  8. Dormitzer P. R., Greenberg H. B. Rotavirus gastroenteritis: basicfacts and prospects for prevention and treatment. In Root R. K., Sande M. A. (eds) Viral infections: diagnosis, treatment and prevention (Contemporary issues in infectious diseases, vol 10.) New York: Churchill Livingstone; 199372–95
    [Google Scholar]
  9. Snodgrass D. R., Browning G. Enteric vaccines for farm animalsand horses. In Peters A. R. (ed) Vaccines for veterinary applications Oxford: Butterworth-Heinemann; 199359–81
    [Google Scholar]
  10. Snodgrass D. R., Wells P. W. Rotavirus infection in lambs: studies on passive protection. Arch Virol 1976; 52:201–205
    [Google Scholar]
  11. Qffit P. A., Clark H. F. Protection against rotavirus-induced gastroenteritis in a murine model by passively acquired gastrointestinal but not circulating antibodies. J Virol 1985; 54:58–64
    [Google Scholar]
  12. Besser T. E., Gray C. C., McGuire T. C., Evermann J. F. Passiveimmunity to bovine rotavirus infection associated with transfer of serum antibody into the intestinal lumen. J Virol 1988; 62:2238–2242
    [Google Scholar]
  13. Conner M. E., Gilger M. A., Estes M. K., Graham D. Y. Serologic and mucosal immune response to rotavirus infection in the rabbit model. J Virol 1991; 65:2562–2571
    [Google Scholar]
  14. Conner M. E., Crawford S. E., Barone C., Estes M. K. Rotavirusvaccine administered parenterally induces protective immunity. J Virol 1993; 67:6633–6641
    [Google Scholar]
  15. Offit P. A., Dudzik K. I. Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection. J Virol 1989; 63:3507–3512
    [Google Scholar]
  16. Offit P. A., Dudzik K. I. Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice. J Virol 1990; 64:6325–6328
    [Google Scholar]
  17. Dharakul T., Rott L., Greenberg H. B. Recovery from chronicrotavirus infection in mice with severe combined immuno-deficiency : virus clearance mediated by adoptive transfer of immune CD8+T lymphocytes. J Virol 1990; 64:4375–4382
    [Google Scholar]
  18. Dharakul T., Labbe M., Cohen J. Immunization with baculovirus-expressed recombinant rotavirus proteins VP 1, VP4, VP6, and VP7 induces CD8+T lymphocytes that mediate clearance of chronic rotavirus infection in SCID mice. J Virol 1991; 65:5928–5932
    [Google Scholar]
  19. Offit P. A., Boyle D. B., Both G. W. Outer capsid glycoprotein vp7 is recognized by cross-reactive, rotavirus-specific, cytotoxic T lymphocytes. Virology 1991; 184:563–568
    [Google Scholar]
  20. Ward R. I., NcNeal M. M., Sheridan J. F. Evidence that active protection following oral immunization of mice with live rotavirus is not dependent on neutralizing antibody. Virology 1992; 188:57–66
    [Google Scholar]
  21. Merchant A. A., Groene W. S., Cheng E. H., Shaw R. D. Murine intestinal antibody response to heterologous rotavirus infection. J Clin Microbiol 1991; 29:1693–1701
    [Google Scholar]
  22. Abraham R., Ogra P. L. Mucosal microenvironment and mucosal response. Am J Trop Med Hyg 1994; 50: Suppl 3–9
    [Google Scholar]
  23. Mattion N., Cohen J., Estes M. K. The rotavirus proteins. In Kapikian A. Z. (ed) Viral infections of the gastrointestinal tract 2nd edn New York: Marcel Dekker; 1994169–249
    [Google Scholar]
  24. McNabb P. C., Tomasi T. B. Host defense mechanisms at mucosalsurfaces. Annu Rev Microbiol 1981; 35:477–496
    [Google Scholar]
  25. Mestecky J., McGhee J. R., Immunoglobulin A. (IgA): molecularand cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol 1987; 40:153–245
    [Google Scholar]
  26. Bishop R. F., Cipriani E., Lund J. S., Barnes G. L., Hosking C. S. Estimation of rotavirus immunoglobulin G antibodies in human serum samples by enzyme-linked immunosorbent assay: expression of results as units derived from a standard curve. J Clin Microbiol 1984; 19:447–452
    [Google Scholar]
  27. Jason J. M., Nieburg P., Marks J. S. Mortality and infectiousdisease associated with infant-feeding practices in developing countries. Pediatrics 1984; 74:702–727
    [Google Scholar]
  28. Gurwith M., Wenman W., Gurwith D., Brunton J., Feltham S., Greenberg H. Diarrhea among infants and young children in Canada: a longitudinal study in three northern communities. J Infect Dis 1983; 147:685–692
    [Google Scholar]
  29. Duffy L. C., Riepenhoff-Talty M., Byers T. E. Modulation ofrotavirus enteritis during breast-feeding. Implications on alterations in the intestinal bacterial flora. Am J Dis Child 1986; 140:1164–1168
    [Google Scholar]
  30. Weinberg R. J., Tipton G., Klish W. J., Brown M. R. Effect of breast-feeding on morbidity in rotavirus gastroenteritis. Pediatrics 1984; 74:250–253
    [Google Scholar]
  31. Hilpert H., Brüssow H., Mietens C., Sidoti J., Lemer L., Werchau H. Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants. J Infect Dis 1987; 156:158–166
    [Google Scholar]
  32. Clemens J., Rao M., Ahmed F. Breast-feeding and the riskof life-threatening rotavirus diarrhea: prevention or postponement?. Pediatrics 1993; 92:680–685
    [Google Scholar]
  33. Jayashree S., Bhan M. K., Kumar R., Bhandari N., Sazawal S. Protection against neonatal rotavirus by breast milk antibodies and trypsin inhibitors. J Med Virol 1988; 26:333–338
    [Google Scholar]
  34. Clark S. M., Roth J. R., Clark M. L., Barnett B. B., Spendlove R. S. Trypsin enhancement of rotavirus infectivity: mechanism of enhancement. J Virol 1981; 39:816–822
    [Google Scholar]
  35. Flores J., Midthun K., Hoshino Y. Conservation of the fourth gene among rotaviruses recovered from asymptomatic newborn infants and its possible role in attenuation. J Virol 1986; 60:972–979
    [Google Scholar]
  36. Petschow B. W., Talbott R. D. Reduction in virus-neutralizing activity of a bovine colostrum immunoglobulin concentrate by gastric acid and digestive enzymes. J Pediatr Gastro-enterol Nutr 1994; 19:228–235
    [Google Scholar]
  37. Yolken R. H., Peterson J. A., Vonderfecht S. L., Fouts E. T., Midthun K., Newburg D. S. Human milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis. J Clin Invest 1992; 90:1984–1991
    [Google Scholar]
  38. Rahman M. M., Yamauchi M., Hanada N., Nishikawa K., Morishima T. Local production of rotavirus specific IgA in breast tissue and transfer to neonates. Arch Dis Child 1987; 62:401–405
    [Google Scholar]
  39. McLean B., Holmes I. H. Transfer of antirotaviral antibodiesfrom mothers to their infants. J Clin Microbiol 1980; 12:320–325
    [Google Scholar]
  40. Hjelt K., Grauballe P. C., Nielsen O. H., Schiotz P. O., Krasilnikoff P. A. Rotavirus antibodies in the mother and her breast-fed infant. J Pediatr Gastroenterol Nutr 1985; 4:414–420
    [Google Scholar]
  41. Bell L. M., Clark H. F., Offit P. A., Slight P. H., Arbeter A. M., Plotkin S. A. Rotavirus serotype-specific neutralizing activity in human milk. Am J Dis Child 1988; 142:275–278
    [Google Scholar]
  42. Cruz J. R., Arevalo C. Fluctuation of specific IgA antibodies inhuman milk. Acta Paediatr Scand 1985; 74:897–903
    [Google Scholar]
  43. Brussow H., Sidoti J., Lemer L. Antibodies to seven rotavirus serotypes in cord sera, maternal sera, and colostrum of German women. J Clin Microbiol 1991; 29:2856–2859
    [Google Scholar]
  44. Ringenbergs M., Albert M. J., Davidson G. P., Goldsworthy W., Haslam R. Serotype-specific antibodies to rotavirus in human colostrum and breast milk and in maternal and cord blood. J Infect Dis 1988; 158:477–480
    [Google Scholar]
  45. Jayashree S., Bhan M. K., Kumar R Raj P., Glass R., Bhandari N. Serum and salivary antibodies as indicators of rotavirus infection in neonates. J Infect Dis 1988; 158:1117–1120
    [Google Scholar]
  46. Aiyar J., Bhan M. K., Bhandari N., Kumar R., Raj P., Sazawal S. Rotavirus-specific antibody response in saliva of infants with rotavirus diarrhea. J Infect Dis 1990; 162:1383–1384
    [Google Scholar]
  47. Grimwood K., Lund J. C. S., Coulson B. S., Hudson I. L., Bishop R. F., Barnes G. L. Comparison of serum and mucosal antibody responses following severe acute rotavirus gastroenteritis in young children. J Clin Microbiol 1988; 26:732–738
    [Google Scholar]
  48. Losonsky G. A., Reymann M. The immune response in primary asymptomatic and symptomatic rotavirus infection in newborn infants. J Infect Dis 1990; 161:330–332
    [Google Scholar]
  49. Sonza S., Holmes I. H. Coproantibody response to rotavirus infection. Med J Aust 1980; 2:496–499
    [Google Scholar]
  50. Riepenhoff-Talty M., Bogger-Goren S., Carmody P. J., Barrett H. J., Ogra P. L. Development of serum and intestinal antibody response to rotavirus after naturally acquired rotavirus infection in man. J Med Virol 1981; 8:215–222
    [Google Scholar]
  51. Hjelt K., Grauballe P. C., Schiotz P. O., Anderson L., Krasilnikoff P. A. Intestinal and serum immune response to a naturally acquired rotavirus gastroenteritis in children. J Pediatr Gastroenterol Nutr 1985; 4:60–66
    [Google Scholar]
  52. Hjelt K., Grauballe P. C., Anderson L., Schiotz P. O., Howitz P., Krasilnikoff P. A. Antibody response in serum and intestine in children up to six months after a naturally acquired rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr 1986; 5:74–80
    [Google Scholar]
  53. Coulson B. S., Grimwood K., Masendycz P. J. Comparison of rotavirus immunoglobulin A coproconversion with other indices of rotavirus infection in a longitudinal study in childhood. J Clin Microbiol 1990; 28:1367–1374
    [Google Scholar]
  54. Matson D. O., O’Ryan M. L., Herrera I., Pickering L. K., Estes M. K. Fecal antibody responses to symptomatic and asymptomatic rotavirus infections. J Infect Dis 1993; 167:577–583
    [Google Scholar]
  55. Mendis L., Senanayake S. Serum and coproantibody responses to rotavirus infection in children during the first two years of life. J Diarrhoea! Dis Res 1993; 5:75–81
    [Google Scholar]
  56. Shinozaki T., Araki K., Ushijima H. Coproantibody response to rotavirus in an outbreak in a day-care nursery. Eur J Pediatr 1986; 144:515–516
    [Google Scholar]
  57. Stals F., Walther F. J., Bruggeman C. A. Faecal and pharyngeal shedding of rotavirus and rotavirus IgA in children with diarrhoea. J Med Virol 1984; 14:333–339
    [Google Scholar]
  58. Shinozaki T, Araki K., Ushijima H., Fujii R. Diagnostic significance of specific IgA coproconversion in rotavirus infection. Eur J Pediatr 1986; 145:581–582
    [Google Scholar]
  59. Davidson G. P., Hogg R. J., Kirubakaran C. P. Serum and intestinal immune response to rotavirus enteritis in children. Infect Immun 1983; 40:447–452
    [Google Scholar]
  60. Guarino A., Canani R. B., Russo S. Oral immunoglobulins for treatment of acute rotaviral gastroenteritis. Pediatrics 1994; 93:12–16
    [Google Scholar]
  61. Barnes G. L., Hewson P. H., McLellan J. A. A randomised trial of oral gammaglobulin in low-birth-weight infants infected with rotavirus. Lancet 1982; 1:1371–1373
    [Google Scholar]
  62. Angeretti A., Magi M. T., Merlino C., Ferrara B., Negro Ponzi A. Specific serum IgA in rotavirus gastroenteritis. J Med Virol 1987; 23:345–349
    [Google Scholar]
  63. Coulson B. S., Grimwood K., Bishop R. F., Barnes G. L. Evaluation of end-point titration, single dilution and capture enzyme immunoassays for measurement of antirotaviral IgA and IgM in infantile secretions and serum. J Virol Methods 1989; 26:53–65
    [Google Scholar]
  64. Brussow H., Werchau H., Lemer L. Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis. J Infect Dis 1988; 158:588–595
    [Google Scholar]
  65. Offit P. A., Hoffenberg E. J., Santos N., Gouvea V. Rotavirus-specific humoral and cellular immune response after primary symptomatic infection. J Infect Dis 1993; 167:1436–1440
    [Google Scholar]
  66. Chiba S., Nakata S., Urasawa T. Protective effect of naturally acquired homotypic and heterotypic rotavirus antibodies. Lancet 1986; 2:417–421
    [Google Scholar]
  67. Ward R. L., Bernstein D. I. for the U. S Rotavirus Vaccine Efficacy Group. Protection against rotavirus disease after natural rotavirus infection. J Infect Dis 1994; 169:900–904
    [Google Scholar]
  68. Kapikian A. Z., Wyatt R. G., Levine M. M. Oral administration of human rotavirus to volunteers: induction of illness and correlates of resistance. J Infect Dis 1983; 147:95–106
    [Google Scholar]
  69. Ward R. L., Bernstein D. I., Shukla R. Effects of antibody to rotavirus on protection of adults challenged with a human rotavirus. J Infect Dis 1989; 159:79–88
    [Google Scholar]
  70. Ward R. L., Bernstein D. I., Young E. C., Sherwood J. R., Knowlton D. R., Schiff G. M. Human rotavirus studies in volunteers: determination of infectious dose and serological response to infection. J Infect Dis 1986; 154:871–880
    [Google Scholar]
  71. Ward R. L., Bernstein D. I., Shukla R. Protection of adults rechallenged with a human rotavirus. J Infect Dis 1990; 161:440–445
    [Google Scholar]
  72. Green K. Y., Kapikian A. Z. Identification of VP7 epitopes associated with protection against human rotavirus illness or shedding in volunteers. Virol 1992; 66:548–553
    [Google Scholar]
  73. Bernstein D. I., Ziegler J. M., Ward R. L. Rotavirus faecal IgA antibody response in adults challenged with human rotavirus. J Med Virol 1986; 20:297–304
    [Google Scholar]
  74. Bernstein D. I., McNeal M. M., Schiff G. M., Ward R. L. Induction and persistence of local rotavirus antibodies in relation to serum antibodies. J Med Virol 1989; 28:90–95
    [Google Scholar]
  75. Ward R. L., Pax K. A., Sherwood J. R., Young E. C., Schiff G. M., Bernstein D. I. Salivary antibody titers in adults challenged with a human rotavirus. J Med Virol 1992; 36:222–225
    [Google Scholar]
  76. Friedman M. G., Segal B., Zedeka R. Serum and salivary responses to oral tetravalent reassortant rotavirus vaccine in newborns. Clin Exp Immunol 1993; 92:194–199
    [Google Scholar]
  77. Glass R. I., Ing D. J., Stoll B. J., Ing R. T. Immune response torotavirus vaccines among breast-fed and nonbreast-fed children. Adv Exp Med Biol 1991; 301:249–254
    [Google Scholar]
  78. Jertbom M., Svennerholm A.-M., Holmgren J. Saliva, breast milk, and serum antibody responses as indirect measures of intestinal immunity after oral cholera vaccination or natural disease. J Clin Microbiol 1986; 24:203–209
    [Google Scholar]
  79. Bishop R. F. Development of candidate rotavirus vaccines. Vaccine 1993; 11:247–254
    [Google Scholar]
  80. Green K., Y Taniguchi K., Mackow E. R., Kapikian A. Z. Homotypic and heterotypic epitope-specific antibody responses in adult and infant rotavirus vaccinees: implications for vaccine development. J Infect Dis 1990; 161:667–679
    [Google Scholar]
  81. Perez-Schael I., Blanco M., Garcia D. Evaluation of the antigenicity and reactogenicity of varying formulations of the rhesus rotavirus-based quadrivalent and the M37 rotavirus vaccine candidates. J Med Virol 1994; 42:330–337
    [Google Scholar]
  82. Haffejee I. E. The status of rotavirus vaccines in 1990. J Infect 1991; 22:119–128
    [Google Scholar]
  83. Arranz E., O’Mahoney S., Barton J. R., Ferguson A. Immunosenescence and mucosal immunity: significant effects of old age on secretory IgA concentrations and intraepithelial lymphocyte counts. Gut 1992; 33:882–886
    [Google Scholar]
  84. Coulson B. S., Grimwood K., Hudson I. L., Barnes G. L., Bishop R. F. Role of coproantibody in clinical protection of children during reinfection with rotavirus. J Clin Microbiol 1992; 30:1678–1684
    [Google Scholar]
  85. Hjelt K., Grauballe P. C., Paerregaard A., Nielsen O. H., Krasilnikoff P. A. Protective effect of preexisting rotavirus-specific immunoglobulin A against naturally acquired rotavirus infection in children. J Med Virol 1987; 21:39–47
    [Google Scholar]
  86. Hjelt K., Grauballe P. C. Protective levels of intestinal rotavirus antibodies. J Infect Dis 1990; 161:352–353
    [Google Scholar]
  87. Coulson B. S., Masendycz P. J. Measurement of rotavirus-neutralizing coproantibody in children by fluorescent focus reduction assay. J Clin Microbiol 1990; 28:1652–1654
    [Google Scholar]
  88. Ferguson A., Humphreys K., Croft N. Results of immuno-globulin tests on faecal extracts are likely to be extremely misleading. Clin Exp Immunol 1995; 99:70–75
    [Google Scholar]
  89. O’Mahoney S., Arranz E., Barton J. R., Ferguson A. Dissociation between systemic and mucosal humoral immune responses in coeliac disease. Gut 1991; 32:29–35
    [Google Scholar]
  90. Ukae S., Nakata S., Adachi N., Kogawa K., Chiba S. Efficacy of rhesus rotavirus vaccine MMU-18006 against gastro-enteritis due to serotype 1 rotavirus. Vaccine 1994; 12:933–939
    [Google Scholar]
  91. O’Ryan M. L., Matson D. O., Estes M. K., Pickering L. K. Anti-rotavirus G type-specific and isotype-specific antibodies in children with natural rotavirus infections. J Infect Dis 1994; 169:504–511
    [Google Scholar]
  92. Chiba S., Nakata S., Ukae S., Adachi N. Virological and serological aspects of immune resistance to rotavirus gastroenteritis. Clin Infect Dis 1993; 16: Suppl 2SI 17–121
    [Google Scholar]
  93. Murphy B. R. Mucosal immunity to viruses. In Ogra P. L., Mestecky J., Lamm E. M., Strober W., McGhee J. R., Bienenstock J. (eds) Handbook of mucosal immunology San Diego: Academic Press; 1994333–343
    [Google Scholar]
  94. Watanabe H., Gust I. D., Holmes I. H. Human rotavirus and its antibody: their coexistence in feces of infants. J Clin Microbiol 1978; 7:405–409
    [Google Scholar]
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