1887

Abstract

Summary

The relative virulence of serotypes A, B, C and D in four mouse strains was assessed by measuring their migration from the foot-pad of the animals to the spleen, lungs and brain in 6-week-old DBA/2, BALB/c, A/J and a hybrid mouse strain by re-isolating yeasts from the internal organs. Comparable doses of each serotype were inoculated into the foot-pads of the mice. var neoformans strains A68, D52, A-(IN) and D-(IN) were more virulent than var gatti strains B112 and C18. However, the differences in the relative virulence of the var neoformans and the var gatti serotypes for the mouse strains were not significant (p > 0.05). Re-isolation of yeasts from mice showed that the BALB/c mice, in particular, and the DBA/2 mice were more susceptible to disseminated infection. The virulence of C. neoformans serotypes through foot-pad inoculation of mice was established.

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1995-10-01
2024-04-25
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References

  1. Kozel T. R. Non-encapsulated variant of Cryptococcus neoformans. II Surface receptors for cryptococcal polysaccharide and their role in inhibition of phagocytosis by polysaccharide. Infect Immun 1977; 16:99–106
    [Google Scholar]
  2. Kozel T. R., Gotschlich E. C. The capsule of Cryptococcus neoformans passively inhibits phagocytosis of the yeast by macrophages. J Immunol 1982; 129:1675–1680
    [Google Scholar]
  3. Salkowski C. A., Bartizal K. F., Balish M. J., Balish E. Colonization and pathogenesis of Cryptococcus neoformans in gnoto-biotic mice. Infect Immun 1987; 55:2000–2005
    [Google Scholar]
  4. Baes H., Van Cutsem J. Primary cutaneous cryptococcosis Dermatologica; 1985; 171:357–361
    [Google Scholar]
  5. Rinaldi M. G., Drutz D. J., Howell A., Sande M. A., Wofsy C. B., Hadley W. K. Serotypes of Cryptococcus neoformans in patients with AIDS. J Infect Dis 1986; 153:642
    [Google Scholar]
  6. Gupta S., Ellis M., Cesario T., Ruhling M., Vayuvegula B. Disseminated cryptococcal infection in a patient with hypogammaglobulinemia and normal T cell functions. Am J Med 1987; 82:129–131
    [Google Scholar]
  7. Abrahams I. Further studies on acquired resistance to murine cryptococcosis: enhancing effect of Bordetella pertussis. J Immunol 1966; 96:525–529
    [Google Scholar]
  8. Dykstra M. A., Friedman L. Pathogenesis, lethality and immunizing effect of experimental cutaneous cryptococcosis. Infect Immun 1978; 20:446–455
    [Google Scholar]
  9. Graybill J. R., Hague M., Drutz D. J. Passive immunization in murine cryptococcosis. Sabouraudia 1981; 19:237–244
    [Google Scholar]
  10. Dromer F., Charriere J., Contrepois A., Carbon C., Yeni P. Protection of mice against experimental Cryptococcus infection by anti-Cryptococcus neoformans monoclonal antibodies. Infect Immun 1987; 55:749–752
    [Google Scholar]
  11. Shibuya K., Naoe S., Uchida K., Yamaguchi H. Histo-pathological study of murine pulmonary cryptococcosis. Jpn J Med Mycol 1988; 29:182–190
    [Google Scholar]
  12. van Cutsem J., Fransen J., van Gerven F., Janssen P. A. J. Experimental cryptococcosis: dissemination of Crypto-coccus neoformans and dermotropism in guinea-pigs. Mykosen 1986; 29:561–575
    [Google Scholar]
  13. Dixon D. M., Polak A. In vivo and in vitro studies with an atypical rhinotropic isolate of Cryptococcus neoformans. Mycopathologia 1986; 96:33–40
    [Google Scholar]
  14. Bergman F. Pathology of experimental cryptococcosis. A study of course and tissue response in subcutaneously induced infection in mice. Acta Pathol Microbiol Scand 1961 Suppl 147:1–163
    [Google Scholar]
  15. Love G. L., Boyd G. A., Greer D. L. Large Cryptococcus neoformans isolated from brain abscess. J Clin Microbiol 1985; 22:1068–1070
    [Google Scholar]
  16. Kwong-Chung K. J., Polacheck I., Bennett J. E. Improved di agnostic medium for separation of Cryptococcus neoformans var neoformans (serotypes A and D) and Cryptococcus neoformans var gatti (serotypes B and C). J Clin Microbiol 1982; 15:535–537
    [Google Scholar]
  17. Jungerman P. F., Schwartzman R. M. Cryptococcosis. In: Vet erinary medical mycology. Philadelphia, Lea and Feibiger 1972151
    [Google Scholar]
  18. Casadevall A., Mukherjee J., Devi S. J. N., Schneerson R., Robbins J. B., Scharff M. D. Antibodies elicited by a Cryptococcus neoformans—tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection. J Infect Dis 1992; 165:1086–1093
    [Google Scholar]
  19. Song M. M. Experimental cryptococcosis of the skin. Sabouraudia 1974; 12:133–137
    [Google Scholar]
  20. Seibold H. R., Roberts C. S., Jordan E. M. Cryptococcosis in a dog. J Am Vet Med Ass 1953; 122:213–115
    [Google Scholar]
  21. Kwon-Chung K. J., Bennett J. E. Epidemiologic differences be tween the two varieties of Cryptococcus neoformans. Am J Epidemiol 1984; 120:123–130
    [Google Scholar]
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