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1887

Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 43, Issue 3

The detection of raised levels of IgM to in sera from patients with rheumatoid arthritis No Access

Abstract

Summary

An analysis by ELISA of 100 rheumatoid factor (RF)-positive sera selected at random from a collection of sera from patients with various auto-immune diseases and joint pains, and 100 RF-negative sera from the same collection matched by patient age and gender, showed that the RF-positive sera had highly significantly (p ≪ 0.0001) raised levels of IgM antibody, but not IgG antibody, to over those of the RF-negative sera. This response was subsequently found to be associated with sera from patients who clinically had rheumatoid arthritis (RA). Sera from the RA patients had significantly greater amounts (p = 0.026) of IgM antibody to than to the other organisms tested and these values were also highly significantly different (p ≪ 0.0001) from IgM antibody levels in matched RF-negative sera. Sera from RA patients also had significantly greater amounts of IgA to (p ≪ 0.0001) and greater amounts of IgM to (p ≪ 0.0001) and (p ≪ 0.0001) than those in matched RF-negative sera. Other classes of antibody to these organisms and all classes of antibody to were not raised in the sera of RA patients over those of RF-negative controls. The IgM response in RA patients was not specific for only one O serotype of but was associated with all 11 different O serotypes of tested and those of other spp. Moreover, the IgM antibodies to spp. appeared to be independent from C-reactive protein and RF. Fourteen of 27 sera from RA patients had an IgM antibody that reacted with an internal 90-kDa protein of . This antibody was not found in RF-positive sera of patients with Sjogren’s disease or systemic lupus erythematosus, nor in other RF-negative sera, nor in those of healthy people, nor in those with osteoarthritis or ankylosing spondylitis. IgM antibodies capable of reacting with the haemolysin protein Hpm B of were not found in sera of RA patients of unknown HLA status.

  • Received:
  • Accepted:
  • Published Online:
© J. MED. MICROBIOL. 1995
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1995-09-01
2025-01-14
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/content/journal/jmm/10.1099/00222615-43-3-176
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The detection of raised levels of IgM to Proteus mirabilis in sera from patients with rheumatoid arthritis
J. Med. Microbiol. 43, 176 (1995); https://doi.org/10.1099/00222615-43-3-176
/content/journal/jmm/10.1099/00222615-43-3-176
/content/journal/jmm/10.1099/00222615-43-3-176
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