1887

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Volume 42, Issue 4

Various species differ in their ability to induce the production of C3, factor B and granulocyte-macrophage colony-stimulating factor (GM-CSF) in human monocyte cultures Free

Abstract

Surmmary

The incidence of infections with and also with non- yeast species is increasing rapidly, particularly in immunocompromised patients. Eight species were compared for their ability to stimulate production of complement components C3 and factor B by monocytes. In addition, the release of granulocytemacrophage colony-stimulating factor (GM-CSF) was determined, because this cytokine affects monocyte complement production. The highest ranked pathogenic yeasts, i.e., , were the most effective inducers of C3, factor B and GM-CSF production. and showed intermediate activity, whereas and had only a moderate stimulatory effect on C3 production and did not affect either factor B or GM-CSF release. The stimulated cytokine and complement production in response to the yeasts was highly variable in monocytes from different donors, but there was a consistent inverse relationship between C3 and GM-CSF concentrations in the monocyte supernates. This is in agreement with the previously described suppressive effect of GM-CSF on yeast-induced C3, but not factor B production. The monocyte responses elicited by a specific yeast species may be linked to its pathogenicity, and may also explain the predilection of some yeasts for particular underlying diseases.

  • Received:
  • Accepted:
  • Published Online:
© J. MED. MICROBIOL. 1995
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1995-04-01
2024-04-24
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Various Candida and Torulopsis species differ in their ability to induce the production of C3, factor B and granulocyte-macrophage colony-stimulating factor (GM-CSF) in human monocyte cultures
J. Med. Microbiol. 42, 291 (1995); https://doi.org/10.1099/00222615-42-4-291
/content/journal/jmm/10.1099/00222615-42-4-291
/content/journal/jmm/10.1099/00222615-42-4-291
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