1887

Abstract

Summary

Addition of human urokinase, a serine proteinase, to in-vitro cultures of strain M2 enhanced bacterial growth. The enhancement of growth depended on the dose of urokinase (10-12500 units) and the enzymic activity of the protein. Other mammalian proteolytic enzymes (trypsin, chymotrypsin, polymorphonuclear leucocyte elastase, thrombin and plasmin) tested did not affect bacterial growth Experiments with clinical isolates of and from burn patients indicated that urokinase could enhance the in-vitro growth of all of these micro-organisms. However, some strain-to-strain variation was noted in the extent of this enhancement. These results indicate that urokinase, which could be released into burn injury sites from either damaged tissues or inflammatory cells, is capable of enhancing the growth of several micro-organisms that commonly infect patients with thermal injuries, particularly under oxygen-limited conditions and when few micro-organisms are present.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-41-4-264
1994-10-01
2020-01-29
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-41-4-264
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error