The molecular basis of the non-expression of coagulase was investigated for 14 coagulase-negative isolates of obtained from different clinical samples. These isolates had typical characteristics such as production of clumping factor, DNAase and protein A, but, with one exception, failed to produce detectable amounts of α-haemolysin. All 14 strains had DNA homologous to the coagulase gene (), but a -specific transcript was found in only seven of them. α-Haemolysin mRNA was detected in only eight strains without direct correlation to -mRNA expression. Thus, coagulase and α-haemolysin deficiencies in may involve either transcriptional or post-transcriptional alterations although additional regulatory factors may influence the expression of both genes.


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