1887

Abstract

Summary

The relationship between , one of the species of the “ group” and was studied in a model of pneumonia in mice and to elucidate mechanisms of pathogenicity in “. group”-associated pulmonary infection. Acute pneumonia with or without empyema and lung abscess in mice with mixed infection resulted in 60% mortality rate, but there was only 10% mortality and mild pneumonia in each separate infection. Bacterial clearance of organisms, especially . , in mixed infection was delayed. Enhancement of growth of . was demonstrated when cultured with . ; growth was also stimulated by a culture filtrate of . which also inhibited bactericidal activity of human neutrophils. In an examination of infectivity and bacterial clearance of . with . culture filtrate , there was 20% mortality and delayed clearance of . , although the infection was not as severe as that produced by the combination of both organisms. These results suggest that . may act with . in the production of pulmonaryinfections by stimulating its growth and suppressing bactericidal activity of the host.

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1994-02-01
2024-04-19
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