1887

Abstract

Summary

The relationship between , one of the species of the “ group” and was studied in a model of pneumonia in mice and to elucidate mechanisms of pathogenicity in “. group”-associated pulmonary infection. Acute pneumonia with or without empyema and lung abscess in mice with mixed infection resulted in 60% mortality rate, but there was only 10% mortality and mild pneumonia in each separate infection. Bacterial clearance of organisms, especially . , in mixed infection was delayed. Enhancement of growth of . was demonstrated when cultured with . ; growth was also stimulated by a culture filtrate of . which also inhibited bactericidal activity of human neutrophils. In an examination of infectivity and bacterial clearance of . with . culture filtrate , there was 20% mortality and delayed clearance of . , although the infection was not as severe as that produced by the combination of both organisms. These results suggest that . may act with . in the production of pulmonaryinfections by stimulating its growth and suppressing bactericidal activity of the host.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-40-2-118
1994-02-01
2024-06-14
Loading full text...

Full text loading...

/deliver/fulltext/jmm/40/2/medmicro-40-2-118.html?itemId=/content/journal/jmm/10.1099/00222615-40-2-118&mimeType=html&fmt=ahah

References

  1. Poole PM, Wilson G. Occurrence and cultural features of Streptococcus milled in various body sites. J Clin Pathol 1979; 32:764–768
    [Google Scholar]
  2. Van der Auwera P. Clinical significance of Streptococcus milleri . Eur J Clin Microbiol 1985; 4:386–390
    [Google Scholar]
  3. Miller SD, Mauff AC, Koornhof HJ. Streptococcus milleri causing infection in man. S Afr Med J 1983; 63:684–686
    [Google Scholar]
  4. Waitkins SA, Ratcliffe JG, Roberts C. Streptococcus milleri found in pulmonary empyemas and abscesses. J Clin Pathol 1985; 38:716–717
    [Google Scholar]
  5. Hocken DB, Dussek JE. Streptococcus milleri as a cause of pleural empyema. Thorax 1985; 40:626–628
    [Google Scholar]
  6. Kohno S, Watanabe K, Hamamoto A. Transthoracic needle aspiration of the lung in respiratory infections. Tohoku J Exp Med 1988; 158:227–235
    [Google Scholar]
  7. Kambal AM. Isolation of Streptococcus milleri from clinical specimens. J Infect 1987; 14:217–223
    [Google Scholar]
  8. Rotstein OD, Pruett TL, Fiegel VD, Nelson RD, Simmons RL. Succinic acid, a metabolic by-product of Bacteroides species, inhibits polymorphonuclear leukocyte function. Infect Immun 1985; 48:402–408
    [Google Scholar]
  9. Bartlett JG. Anaerobic bacterial infections of the lung. Chest 1987; 91:901–909
    [Google Scholar]
  10. Finegold SM. Anaerobic pulmonary infection. Hosp Pract 1989; 15:103–133
    [Google Scholar]
  11. Rotstein OD, Pruett TL, Simmons RL. Mechanisms of microbial synergy in polymicrobial surgical infections. Rev Infect Dis 1985; 7:151–170
    [Google Scholar]
  12. Mergenhagen SE, Thonard JC, Scherp HW. Studies on synergistic infections. I. Experimental infections with anaerobic streptococci. J Infect Dis 1958; 103:33–44
    [Google Scholar]
  13. Jones GR, Gemmell CG. Impairment by Bacteroides species of opsonisation and phagocytosis of enterobacteria. J Med Microbiol 1982; 15:351–361
    [Google Scholar]
  14. Ingham HR, Sisson PR, Tharagonnet D, Selkon JB, Codd AA. Inhibition of phagocytosis in vitro by obligate anaerobes. Lancet 1977; 2:1252–1254
    [Google Scholar]
  15. Namavar F, Verweij AMJJ, Bal M, van Steenbergen TJM, de Graaff J, McLaren DM. Effect of anaerobic bacteria on killing of Proteus mirabilis by human polymorphonuclear leukocytes. Infect Immun 1983; 40:930–935
    [Google Scholar]
  16. Okuda K, Takozoe I. Antiphagocytic effects of the capsular structure of a pathogenic strain of Bacteroides melanino-genicus . Bull Tokyo Dent Coll 1973; 14:99–104
    [Google Scholar]
  17. Brook I, Walker RL. The role of encapsulation in the pathogenesis of anaerobic gram-positive cocci. Can J Microbiol 1985; 31:176–180
    [Google Scholar]
  18. Unsworth PF. Hyaluronidase production in Streptococcus milleri in relation to infection. J Clin Pathol 1989; 42:506–510
    [Google Scholar]
  19. Steffen EK, Hentges DJ. Hydrolytic enzymes of anaerobic bacteria isolated from human infections. J Clin Microbiol 1981; 14:153–156
    [Google Scholar]
  20. Ruoff KL, Ferraro MJ. Hydrolytic enzymes of “Streptococcus milleri” . J Clin Microbiol 1987; 25:1645–1647
    [Google Scholar]
  21. Arala-Chaves MP, Higerd TB, Porto MT. Evidence for the synthesis and release of strongly immunosuppressive, noncytotoxic substances by Streptococcus intermedius . J Clin Invest 1979; 64:871–883
    [Google Scholar]
  22. Rudek W, Haque R-U. Extracellular enzymes of the genus Bacteroides . J Clin Microbiol 1976; 4:458–460
    [Google Scholar]
  23. Tresadern JC, Farrand RJ, Irving MH. Streptococcus milleri and surgical sepsis. Ann R Coll Surg Engl 1983; 65:78–79
    [Google Scholar]
  24. Lewis MAO, Macfarlane TW, Mcgowan DA, MacDonald DG. Assessment of the pathogenicity of bacterial species isolated from acute dentoalveolar abscesses. J Med Microbiol 1988; 27:109–116
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-40-2-118
Loading
/content/journal/jmm/10.1099/00222615-40-2-118
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error