Lysozyme production by members of the Micrococeaceae was tested for by a plate method. All coagulase-positive staphylococci and a number of other staphylococci and micrococci produced lysozyme.

Many coagulase-negative staphylococci and micrococci from infections of the urinary tract produced lysozyme, particularly those belonging to subgroup 3 in Baird-Parker's scheme, but lysozyme production was more frequent in urinary than in skin strains, not only in this subgroup but in several other subgroups of staphylococci and micrococci.

Coagulase-negative staphylococci that colonised internal artificial prostheses rarely produced lysozyme. It is suggested that cocci that cause indolent colonisation of internal prostheses are not pathogenic in the conventional sense.

I acknowledge gratefully the advice of Dr R. L. Newman and Professor M. R. J. Salton. The co-operation of all workers from whom cultures were received was invaluable; these include Mr W. Hamilton, Dr T. A. MacAllister, Dr R. G. Mitchell, Dr N. Mortensen, Dr G. C. Turner and Professor R. E. O. Williams. Miss Judith Smith kindly gave much skilled assistance.


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