1887

Abstract

SUMMARY

A series of complex immunological changes occur in the lungs of mice infected with Sendai virus. Early in the infection a rapid increase occurs in the number of immunoglobulin-containing cells in the vicinity of infected mucosal cells. Qualitative and quantitative changes occur in the immunoglobulins and other serum proteins in the bronchial secretions at the time of the inflammatory response. High immunoglobulin levels in the bronchial secretions persist long after the inflammatory changes have subsided. The concentrations of detectable specific antibody do not increase until after the commencement of the viral eradication process.

The possible significance of these changes in the termination of primary virus infections is discussed.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-4-3-351
1971-08-01
2021-10-24
Loading full text...

Full text loading...

/deliver/fulltext/jmm/4/3/medmicro-4-3-351.html?itemId=/content/journal/jmm/10.1099/00222615-4-3-351&mimeType=html&fmt=ahah

References

  1. Alford R. H., Rossen R. D., Butler W. T., Kassel J. A. 1967; Neutralizing and haemagglutination-inhibiting activity of nasal secretions following experimental human infection with A2 influenza virus. J. Immun 98:724
    [Google Scholar]
  2. Artenstein M. S., Bellanti J. A., Buescher E. L. 1964; Identification of the antiviral substances in nasal secretions.Proc.Soc.Exp.Biol. Med 117:558
    [Google Scholar]
  3. Hall J. G. 1969; Effector mechanisms in immunity. Lancet 1:25
    [Google Scholar]
  4. Robinson T. W. E., Cureton R. J. R., Heath R. B. 1968; The pathogenesis of Sendai virus infection in the mouse lung.J.Med. Microbiol 1:89
    [Google Scholar]
  5. Robinson T. W. E., Cureton R. J. R., Heath R. B. 1969; The effect of cyclophosphamide on Sendai virus infection of mice.J.Med. Microbiol 2:137
    [Google Scholar]
  6. Sainte-Marie G. 1962; A paraffin embedding technique for studies employing immunofluorescence.J.Histochem. Cytochem 10:250
    [Google Scholar]
  7. Scheidegger J. J. 1955; Une micro-méthode de l’immuno-électrophorèse. Int. Archs. Allergy Appl. Immun 7:103
    [Google Scholar]
  8. Smith C. B., Bellanti J. A., Chanock R. M. 1967; Immunoglobulins in serum and nasal secretions following infection with type I parainfluenza virus and injection of inactivated vaccines.J. Immun 99:133
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-4-3-351
Loading
/content/journal/jmm/10.1099/00222615-4-3-351
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error